Abstract
Application of chemometric methods in the study of the retention indices of thirteen 5-arylidene-2,4- thiazolidinediones in two low polarity high-performance thin-layer chromatographic (HPTLC) stationary phases (RP-18 and RP-CN) and six aqueous mobile phases. Principal component analysis classified chromatographic systems into four specific groups while one system remained non-classified. Hierarchical clustering analysis enabled grouping of the chromatographic systems into three clusters, and the studied compounds into three main classes. The color map enabled more in-depth interpretation of the relationships between the studied compounds and HPTLC systems applied.
Keywords: 5-arylidene-2, 4-thiazolidinediones, classification, color map, dendrogram, HCA, PCA.
Combinatorial Chemistry & High Throughput Screening
Title:Chemometric Study of Retention Indices of Some Thiazolidinediones Derivatives in Two Low Polarity Stationary Phases
Volume: 17 Issue: 7
Author(s): Adam Smolinski and Tatjana Lj. Djakovic-Sekulic
Affiliation:
Keywords: 5-arylidene-2, 4-thiazolidinediones, classification, color map, dendrogram, HCA, PCA.
Abstract: Application of chemometric methods in the study of the retention indices of thirteen 5-arylidene-2,4- thiazolidinediones in two low polarity high-performance thin-layer chromatographic (HPTLC) stationary phases (RP-18 and RP-CN) and six aqueous mobile phases. Principal component analysis classified chromatographic systems into four specific groups while one system remained non-classified. Hierarchical clustering analysis enabled grouping of the chromatographic systems into three clusters, and the studied compounds into three main classes. The color map enabled more in-depth interpretation of the relationships between the studied compounds and HPTLC systems applied.
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Cite this article as:
Smolinski Adam and Djakovic-Sekulic Lj. Tatjana, Chemometric Study of Retention Indices of Some Thiazolidinediones Derivatives in Two Low Polarity Stationary Phases, Combinatorial Chemistry & High Throughput Screening 2014; 17 (7) . https://dx.doi.org/10.2174/1386207317666140509102101
DOI https://dx.doi.org/10.2174/1386207317666140509102101 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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