Endothelial Cell Regulation of Cardiac Metabolism Following Diabetes

Title:Endothelial Cell Regulation of Cardiac Metabolism Following Diabetes

Volume: 14 Issue: 2

Author(s): Fang Wang, Dahai Zhang, Andrea Wan and Brian Rodrigues

Affiliation:

Keywords: Cardiomyopathy, fatty acids, heparanase, LPL, metabolism, VEGF.

Abstract: The earliest change that occurs in the diabetic heart is reduced glucose consumption, with a switch to utilization of fatty acids (FA) predominantly as an energy resource. Although this adaptation might be beneficial in the short-term, over a protracted duration, it is potentially catastrophic given the malicious effects produced by high FA in cardiomyocytes. In this review, we describe how the endothelial cell (EC), a “first-responder” to hyperglycemia, communicates with the underlying cardiomyocyte. As this cross-talk is expected to facilitate increased FA delivery to, and utilization by, the cardiomyocyte, understanding this conversationshould assist in devising new therapeutic strategies to prevent or delay diabetic heart disease.

Cite this article as:

Wang Fang, Zhang Dahai, Wan Andrea and Rodrigues Brian, Endothelial Cell Regulation of Cardiac Metabolism Following Diabetes, Cardiovascular & Hematological Disorders-Drug Targets 2014; 14 (2) . https://dx.doi.org/10.2174/1871529X14666140505123221