Abstract
The present work proposes a simple, accurate and low-cost method employing simultaneous detection (conductometric and potentiometric) during a precipitation titration using silver nitrate as titrant for diltiazem hydrochloride (DTZ) determination. Both methods were based on the chemical reaction between chloride ions coming from diltiazem hydrochloride molecule and Ag(I) ions, yielding the precipitate AgCl(s). The conductance of the solution and the electric potential of the cell (using an Ag-wire electrode) were measured as a function of the volume of titrant. Under optimized experimental conditions the method was applied for DTZ determination in pharmaceuticals and the results obtained are in close agreement with those obtained using an official method proposed by the British Pharmacopoeia.
Keywords: Conductometric titration, potentiometric titration, diltiazem determination.
Current Pharmaceutical Analysis
Title:A Simple and Precise Determination of Diltiazem Hydrochloride by Simultaneous Conductometric and Potentiometric Detection
Volume: 10 Issue: 3
Author(s): Barbara Viero de Noronha, Mauricio Alberto Poletti Papi, Marcio Fernando Bergamini and Luiz Humberto Marcolino-Junior
Affiliation:
Keywords: Conductometric titration, potentiometric titration, diltiazem determination.
Abstract: The present work proposes a simple, accurate and low-cost method employing simultaneous detection (conductometric and potentiometric) during a precipitation titration using silver nitrate as titrant for diltiazem hydrochloride (DTZ) determination. Both methods were based on the chemical reaction between chloride ions coming from diltiazem hydrochloride molecule and Ag(I) ions, yielding the precipitate AgCl(s). The conductance of the solution and the electric potential of the cell (using an Ag-wire electrode) were measured as a function of the volume of titrant. Under optimized experimental conditions the method was applied for DTZ determination in pharmaceuticals and the results obtained are in close agreement with those obtained using an official method proposed by the British Pharmacopoeia.
Export Options
About this article
Cite this article as:
Viero de Noronha Barbara, Alberto Poletti Papi Mauricio, Fernando Bergamini Marcio and Humberto Marcolino-Junior Luiz, A Simple and Precise Determination of Diltiazem Hydrochloride by Simultaneous Conductometric and Potentiometric Detection, Current Pharmaceutical Analysis 2014; 10 (3) . https://dx.doi.org/10.2174/1573412910666140403000201
DOI https://dx.doi.org/10.2174/1573412910666140403000201 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
OPA1 in Cardiovascular Health and Disease
Current Drug Targets Metabolic Syndrome, Dyslipidemia and Regulation of Lipoprotein Metabolism
Current Diabetes Reviews Separation and Purification of Small Peptides from Fermented Sesame Meal and Their Antioxidant Activities
Protein & Peptide Letters Role of microRNAs in Vascular Remodeling
Current Molecular Medicine MicroRNAs Determining Inflammation as Novel Biomarkers and Potential Therapeutic Targets
Current Medicinal Chemistry Ambulatory Blood Pressure Monitoring in Type 2 Diabetes Mellitus: A Cross-sectional Study
Current Hypertension Reviews Calcium Related Genes in Dogs as Potential Cardiac Biomarkers for the Detection of Chronic Mitral Valve Disease
Recent Patents on Biomarkers SGLT-2 inhibitors in Diabetic Kidney Disease: What Lies Behind their Renoprotective Properties?
Current Medicinal Chemistry Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[3,4-b][1,3,4]Thiadiazoles and [1,2,4]Triazolo[3,4-b][1,3,4]Thiadiazines
Letters in Drug Design & Discovery Acute Myocardial Infarction: High Risk Ventricular Tachyarrhythmias and Admission Glucose Level in Patients with and without Diabetes Mellitus
Current Diabetes Reviews Organ- and Cell-Type Specific Delivery of Kinase Inhibitors: A Novel Approach in the Development of Targeted Drugs
Current Molecular Pharmacology Risk Factors for Nevirapine-Associated Rash Among HIV-Infected Patients with Low CD4 Cell Counts in Resource-Limited Settings
Current HIV Research Editorial from Editor-in-Chief (SCUBA Diving and Changes in Lung Function: Where is the Data?)
Current Respiratory Medicine Reviews Molecular Pathways of Endothelial Cell Activation for (Targeted) Pharmacological Intervention of Chronic Inflammatory Diseases
Current Vascular Pharmacology Integrating Qualitative and Quantitative Tools for the Detection and Identification of Lectins in Major Human Diseases
Protein & Peptide Letters Plant Extracts and their Secondary Metabolites as Modulators of Kinases
Current Topics in Medicinal Chemistry Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry
Current Medicinal Chemistry Genetic Predisposition in NAFLD and NASH: Impact on Severity of Liver Disease and Response to Treatment
Current Pharmaceutical Design The Heat Stress Response and Diabetes: More Room for Mitochondrial Implication
Current Pharmaceutical Design The Role of microRNAs in the Initiation and Progression of Stable Atheromatous Plaque
Current Pharmaceutical Design