Synthesis of 2`-hydroxy-4`-isoprenyloxychalcone Derivatives with Potential Antidepressant-like Activity

Title:Synthesis of 2`-hydroxy-4`-isoprenyloxychalcone Derivatives with Potential Antidepressant-like Activity

Volume: 10 Issue: 8

Author(s): Chao Xie, Zhou Peng, Shui-Lian Zhao, Cheng-Yan Pan, Li-Ping Guan and Xian-Yu Sun

Affiliation:

Keywords: 2´-Hydroxy-4´-isoprenyloxychalcone, synthesis, antidepressant-like activity, yohimbine, 5-hydroxytryptophan.

Abstract: A series of 2´-hydroxy-4´-isoprenyloxychalcone derivatives was synthesized and evaluated for its antidepressant- like activity using the FST and TST. All compounds exhibited the potential antidepressant-like activity in the FST and the TST through intraperitoneal injection. Among them, compounds 4i, 4l and 4n exhibited more potent antidepressant- like activity at a dose of 10 mg/kg. And, compounds 4i, 4l and 4n were also adequately absorbed in mice after oral administration at a dose of 30 mg/kg. In the 5-HT induced head-twitch test and yohimbine induced mortality test, compound 4i could increase the head-twitch and rise mortality in mice. The results suggested that the antidepressant effects of compound 4i may be related to via the serotonergic and noradrenergic system.

Cite this article as:

Xie Chao, Peng Zhou, Zhao Shui-Lian, Pan Cheng-Yan, Guan Li-Ping and Sun Xian-Yu, Synthesis of 2`-hydroxy-4`-isoprenyloxychalcone Derivatives with Potential Antidepressant-like Activity, Medicinal Chemistry 2014; 10 (8) . https://dx.doi.org/10.2174/1573406410666140328125641