Abstract
Peptide-based nanoparticles (pep-NPs) are emerging as promising imaging and therapeutic agents against cancer due to their biocompatibility and tunability. Optimized design of the peptide sequence and moderate conjugation of the sequence with extraneous molecules are crucial to the performance of the inherent properties of pep-NPs such as nanostructure formation and ability of drug delivery. Meanwhile, the peptide sequences based on natural/unnatural amino acids could be utilized for designing nanostructures susceptive/resistant to specific enzymes. Herein, we firstly summarize the basic peptide structures to provide a whole image of pep-NPs. Subsequently, the diagnostic strategies based on different imaging modalities and recent therapeutic applications of pep-NPs for cancer are reviewed.
Keywords: Cancer, diagnosis, drug delivery, imaging, peptide-based nanoparticles, therapy.
Current Medicinal Chemistry
Title:Peptide-Based Nanostructures for Cancer Diagnosis and Therapy
Volume: 21 Issue: 21
Author(s): Linna An, M. Rehan H. Shah Gilani and Gaolin Liang
Affiliation:
Keywords: Cancer, diagnosis, drug delivery, imaging, peptide-based nanoparticles, therapy.
Abstract: Peptide-based nanoparticles (pep-NPs) are emerging as promising imaging and therapeutic agents against cancer due to their biocompatibility and tunability. Optimized design of the peptide sequence and moderate conjugation of the sequence with extraneous molecules are crucial to the performance of the inherent properties of pep-NPs such as nanostructure formation and ability of drug delivery. Meanwhile, the peptide sequences based on natural/unnatural amino acids could be utilized for designing nanostructures susceptive/resistant to specific enzymes. Herein, we firstly summarize the basic peptide structures to provide a whole image of pep-NPs. Subsequently, the diagnostic strategies based on different imaging modalities and recent therapeutic applications of pep-NPs for cancer are reviewed.
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Cite this article as:
An Linna, Shah Gilani H. M. Rehan and Liang Gaolin, Peptide-Based Nanostructures for Cancer Diagnosis and Therapy, Current Medicinal Chemistry 2014; 21 (21) . https://dx.doi.org/10.2174/0929867321666140205140600
DOI https://dx.doi.org/10.2174/0929867321666140205140600 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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