Enantioselective Transfer Reaction of Phenyl to Aldehydes Using LProline- Derived Amino Alcohols as Chiral Ligands

Title:Enantioselective Transfer Reaction of Phenyl to Aldehydes Using LProline- Derived Amino Alcohols as Chiral Ligands

Volume: 11 Issue: 5

Author(s): Yongmin Liu, Rongcheng Bo, Nan Wu, Yuehua Qiao, Yong Li, Hui Wu and Zhou Xu

Affiliation:

Keywords: Tertiary amino alcohol, transfer reaction, phenylboronic acid, diethyl zinc, diarylmethanols.

Abstract: ((S)-1-(1,3,5-trimethyl)benzylpyrrolidin-2-yl)diphenylmethanol (1d) was found to be an effective chiral ligand in the asymmetric transfer reaction of phenyl to aldehydes to give the corresponding adducts in excellent enantioselectivity (up to 98% ee) with very high yields (up to 99%).

Cite this article as:

Liu Yongmin, Bo Rongcheng, Wu Nan, Qiao Yuehua, Li Yong, Wu Hui and Xu Zhou, Enantioselective Transfer Reaction of Phenyl to Aldehydes Using LProline- Derived Amino Alcohols as Chiral Ligands, Letters in Organic Chemistry 2014; 11 (5) . https://dx.doi.org/10.2174/1570178611666140124000908