Abstract
We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound synthesis with a methodology that is clean, economical and efficient.
Keywords: Green chemistry, heterocycle, indole, iodine, isatin, propylene carbonate.
Current Organic Synthesis
Title:A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent
Volume: 11 Issue: 4
Author(s): Priscila N. de Azevedo, Leina S. Behenck, Josue S. Bello Forero, July A. Hernandez Munoz, Erika M. de Cavalho, Joel Jones Junior and e Flavia M. da Silva
Affiliation:
Keywords: Green chemistry, heterocycle, indole, iodine, isatin, propylene carbonate.
Abstract: We prepared a series of bis-indole derivatives from different aldehydes and/or substituted isatins using molecular iodine as a catalyst and propylene carbonate as a “green” solvent. Simply stirring the components at room temperature produced high yield compound synthesis with a methodology that is clean, economical and efficient.
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Cite this article as:
Azevedo N. de Priscila, Behenck S. Leina, Forero S. Bello Josue, Munoz A. Hernandez July, Cavalho M. de Erika, Junior Jones Joel and Silva Flavia M. da e, A Sustainable Approach to Bis-Indole Synthesis Using Propylene Carbonate as an Eco-Friendly Solvent, Current Organic Synthesis 2014; 11 (4) . https://dx.doi.org/10.2174/1570179411666140115225758
DOI https://dx.doi.org/10.2174/1570179411666140115225758 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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