Abstract
In the present study, ethosomal and liposomal formulations containing tamoxifen citrate were prepared and evaluated for their penetration properties in human cadaver skin using Franz diffusion cell and confocal laser scanning microscope (CLSM). The results clearly revealed that ethosomal vesicles showed a better drug permeation profile than that of liposomal vesicles. In addition, low fluorescence intensity in CLSM was recorded with liposomes as compared to ethosomes, indicating lower cumulative amount of drug permeation from liposomal vesicles. Furthermore, CLSM showed uniform fluorescence intensity across the entire depth of skin in ethosomal treatment, indicating high penetrability of ethosomal vesicles through human cadaver skin. In contrast, low penetrability of conventional liposomal vesicles was recorded as penetration was limited to the 7th section (i.e. upper epidermis layer) of skin as evident from visualization of intact liposomal vesicles in CLSM.
Keywords: CLSM, Ethosomes, Liposomes, Tamoxifen citrate.
Current Drug Delivery
Title:Penetration of Tamoxifen Citrate Loaded Ethosomes and Liposomes Across Human Skin: A Comparative Study with Confocal Laser Scanning Microscopy
Volume: 11 Issue: 3
Author(s): Khomendra K. Sarwa, Preeti K. Suresh, Mithun Rudrapal and Vinod K. Verma
Affiliation:
Keywords: CLSM, Ethosomes, Liposomes, Tamoxifen citrate.
Abstract: In the present study, ethosomal and liposomal formulations containing tamoxifen citrate were prepared and evaluated for their penetration properties in human cadaver skin using Franz diffusion cell and confocal laser scanning microscope (CLSM). The results clearly revealed that ethosomal vesicles showed a better drug permeation profile than that of liposomal vesicles. In addition, low fluorescence intensity in CLSM was recorded with liposomes as compared to ethosomes, indicating lower cumulative amount of drug permeation from liposomal vesicles. Furthermore, CLSM showed uniform fluorescence intensity across the entire depth of skin in ethosomal treatment, indicating high penetrability of ethosomal vesicles through human cadaver skin. In contrast, low penetrability of conventional liposomal vesicles was recorded as penetration was limited to the 7th section (i.e. upper epidermis layer) of skin as evident from visualization of intact liposomal vesicles in CLSM.
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Cite this article as:
Sarwa K. Khomendra, Suresh K. Preeti, Rudrapal Mithun and Verma K. Vinod, Penetration of Tamoxifen Citrate Loaded Ethosomes and Liposomes Across Human Skin: A Comparative Study with Confocal Laser Scanning Microscopy, Current Drug Delivery 2014; 11 (3) . https://dx.doi.org/10.2174/1567201811666140115113127
DOI https://dx.doi.org/10.2174/1567201811666140115113127 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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