Abstract
Tuberculosis (TB) is an infectious disease caused mainly by members of Mycobacterium tuberculosis complex. In 2012, the WHO estimated 8.7 million new cases and 1.4 million deaths caused by this disease. Under the Millennium Development Goals, the WHO aims to eradicate TB as a public health problem by 2050. However, reaching this goal will require the development and incorporation of new and more effective vaccines that can replace the current BCG vaccine. Much work is therefore ongoing in terms of the development of TB vaccines and more than 10 candidate vaccines are progressing well through the different development stages. The aim of this mini-review is to describe the characteristics of the most promising vaccines, and to give a brief description of some key elements relating to the current and future development of vaccines against TB.
Keywords: BCG, Development, Tuberculosis, Vaccine.
Current Pharmaceutical Biotechnology
Title:Update on the Development of TB Vaccines
Volume: 14 Issue: 11
Author(s): Roberto Zenteno-Cuevas
Affiliation:
Keywords: BCG, Development, Tuberculosis, Vaccine.
Abstract: Tuberculosis (TB) is an infectious disease caused mainly by members of Mycobacterium tuberculosis complex. In 2012, the WHO estimated 8.7 million new cases and 1.4 million deaths caused by this disease. Under the Millennium Development Goals, the WHO aims to eradicate TB as a public health problem by 2050. However, reaching this goal will require the development and incorporation of new and more effective vaccines that can replace the current BCG vaccine. Much work is therefore ongoing in terms of the development of TB vaccines and more than 10 candidate vaccines are progressing well through the different development stages. The aim of this mini-review is to describe the characteristics of the most promising vaccines, and to give a brief description of some key elements relating to the current and future development of vaccines against TB.
Export Options
About this article
Cite this article as:
Zenteno-Cuevas Roberto, Update on the Development of TB Vaccines, Current Pharmaceutical Biotechnology 2013; 14 (11) . https://dx.doi.org/10.2174/1389201014666131226124940
DOI https://dx.doi.org/10.2174/1389201014666131226124940 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Protein Kinase Homology Models: Recent Developments and Results
Current Medicinal Chemistry Chemistry and Biology of Indoles and Indazoles: A Mini-Review
Mini-Reviews in Medicinal Chemistry Predicting Experimental Properties of Proteins from Sequence by Machine Learning Techniques
Current Protein & Peptide Science Patent Selections
Recent Patents on Drug Delivery & Formulation Particulate Systems as Adjuvants and Carriers for Peptide and Protein Antigens
Current Drug Delivery Synthesis and Antimicrobial Activity of Nitroalkenyl Arenes
Anti-Infective Agents Patent Selections
Recent Patents on Nanomedicine Role of Lipopolysaccharides in Potential Applications of Nanocarrier Systems
Current Pharmaceutical Design Emergence of Lipid-Based Vesicular Carriers as Nanoscale Pharmacotherapy in Rheumatoid Arthritis
Recent Patents on Nanomedicine Context-Dependent Regulation of Nrf2/ARE Axis on Vascular Cell Function during Hyperglycemic Condition
Current Diabetes Reviews B-Cell Based Gene Therapy for Autoimmune Diseases
Infectious Disorders - Drug Targets HIV-Tuberculous Meningitis Co-Infection: A Systematic Review and Meta-Analysis
Current Pharmaceutical Biotechnology Relevance of Anxiety and Depression in Chronic Obstructive Pulmonary Disease (COPD)
Current Respiratory Medicine Reviews NAD in Skin: Therapeutic Approaches for Niacin
Current Pharmaceutical Design New Approaches for the Treatment of Chagas Disease
Current Drug Targets Bicyclic 6 + 6 Systems: Advances in the Chemistry of Heterocyclic Compounds Incorporated Pyrimido[1,2-a]Pyrimidine Skeleton
Mini-Reviews in Organic Chemistry Aspartame Induce Modification in Membrane Bound and Antioxidant Enzymes in Liver and Kidney of Wistar Albino Rats
Current Nutrition & Food Science In Search of New Cures for Tuberculosis
Medicinal Chemistry Nanoemulsion for the Effective Treatment and Management of Anti-tubercular Drug Therapy
Recent Patents on Anti-Infective Drug Discovery Expression, Purification, Crystallization and Preliminary X-Ray Crystallographic Analysis of the Peptidoglycan Binding Region of the Ser/Thr Kinase PrkC from Staphylococcus aureus
Protein & Peptide Letters