Abstract
The systematical associations between stroke and coronary heart disease (CHD) remain controversial and uncertain. Network construction and modularized analysis have become powerful tools in the field of systems biology research, which can help us to mine the multidimensional characters of correlation between the two diseases in depth. A total of 218 stroke-related and 204 CHD-related genes were identified via the Online Mendelian Inheritance in Man database; text searching engine (Agilent Literature Search 2.71) and MCODE software were employed for network construction and module division, respectively. Finally, 67, 21, 7, and 196 overlapping genes, hubs, modules and modular functions were identified between stroke and CHD, respectively. The overlapping genes, which should be responsible for the similar phenotypes, highlighted the molecular signatures of the two linked diseases. Additionally, the analysis of modules and their functional annotations showed potential dependent and independent risk factors, such as atherosclerosis, cholesterol homeostasis, plasma lipoprotein particle remodeling and response to oxidative stress, etc. Moreover, the potential mechanisms by which the same biological process activating pathological cascade or risk component-based shared pathway between stroke and CHD were uncovered, which may provide useful insights for further drug development and cost saving.
Keywords: Co-pathogenic analysis, coronary heart disease, drug target prediction, gene interaction network, modularized analysis, stroke.
CNS & Neurological Disorders - Drug Targets
Title:Significant Overlapping Modules and Biological Processes Between Stroke and Coronary Heart Disease
Volume: 13 Issue: 4
Author(s): Yingying Zhang, Pengyun Kong, Yinying Chen, Yanan Yu, Jun Liu, Liqiang Yang, Tao Zhao, Jingyi Nan and Zhong Wang
Affiliation:
Keywords: Co-pathogenic analysis, coronary heart disease, drug target prediction, gene interaction network, modularized analysis, stroke.
Abstract: The systematical associations between stroke and coronary heart disease (CHD) remain controversial and uncertain. Network construction and modularized analysis have become powerful tools in the field of systems biology research, which can help us to mine the multidimensional characters of correlation between the two diseases in depth. A total of 218 stroke-related and 204 CHD-related genes were identified via the Online Mendelian Inheritance in Man database; text searching engine (Agilent Literature Search 2.71) and MCODE software were employed for network construction and module division, respectively. Finally, 67, 21, 7, and 196 overlapping genes, hubs, modules and modular functions were identified between stroke and CHD, respectively. The overlapping genes, which should be responsible for the similar phenotypes, highlighted the molecular signatures of the two linked diseases. Additionally, the analysis of modules and their functional annotations showed potential dependent and independent risk factors, such as atherosclerosis, cholesterol homeostasis, plasma lipoprotein particle remodeling and response to oxidative stress, etc. Moreover, the potential mechanisms by which the same biological process activating pathological cascade or risk component-based shared pathway between stroke and CHD were uncovered, which may provide useful insights for further drug development and cost saving.
Export Options
About this article
Cite this article as:
Zhang Yingying, Kong Pengyun, Chen Yinying, Yu Yanan, Liu Jun, Yang Liqiang, Zhao Tao, Nan Jingyi and Wang Zhong, Significant Overlapping Modules and Biological Processes Between Stroke and Coronary Heart Disease, CNS & Neurological Disorders - Drug Targets 2014; 13 (4) . https://dx.doi.org/10.2174/1871527312666131223115112
DOI https://dx.doi.org/10.2174/1871527312666131223115112 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Hybrid Molecules Development: A Versatile Landscape for the Control of Antifungal Drug Resistance: A Review
Mini-Reviews in Medicinal Chemistry Medications not Intended for Treatment of Dyslipidemias and with a Variable Effect on Lipids
Current Pharmaceutical Design Bacterial Urease and its Role in Long-Lasting Human Diseases
Current Protein & Peptide Science Inflammatory Biomarkers and Therapeutic Targets in Heart Failure
Current Medicinal Chemistry Glucose Sensors Based on Core@Shell Magnetic Nanomaterials and Their Application in Diabetes Management: A Review
Current Pharmaceutical Design Long Term Complications in Pediatric Liver Transplant Recipients: What Every Pediatrician Should Know
Current Pediatric Reviews The Antioxidants and Pro-Antioxidants Network: An Overview
Current Pharmaceutical Design Synthetic Thioamide, Benzimidazole, Quinolone and Derivatives with Carboxylic Acid and Ester Moieties: A Strategy in the Design of Antituberculosis Agents
Current Medicinal Chemistry Management of COVID-19 very Elderly Patients in Nursing Homes and Long-Term Care Facilities: Description of a New Model and Experience in a Medicalized Nursing Home
Coronaviruses Independent Relationship between Serum Osteocalcin and Uric Acid in a Cohort of Apparently Healthy Obese Subjects
Endocrine, Metabolic & Immune Disorders - Drug Targets Vascular and Cardiac Oxidative Stress and Inflammation as Targets for Cardioprotection
Current Pharmaceutical Design New Anti-Anginal Drugs: Ranolazine
Cardiovascular & Hematological Agents in Medicinal Chemistry Bio-Antioxidants – A Chemical Base of Their Antioxidant Activity and Beneficial Effect on Human Health
Current Medicinal Chemistry Can We Move Forward After ADVANCE?
Vascular Disease Prevention (Discontinued) Adjuvant Therapies of COVID-19 - A Literature Review
Coronaviruses New Targets for Anticoagulation and Future Perspectives
Current Drug Discovery Technologies The Prevalence of Frailty in Patients Admitted to Hospital with Vertebral Fragility Fractures
Current Rheumatology Reviews The Applications of Pharmacogenomics to Neurological Disorders
Current Molecular Medicine Host Defence Cryptides from Human Apolipoproteins: Applications in Medicinal Chemistry
Current Topics in Medicinal Chemistry Molecular Genetics and Targeted Therapy in Hepatocellular Carcinoma
Current Cancer Drug Targets