Abstract
In this work we evaluated the suitability of three synthetic membranes for the in vitro assessment of drug release from semisolid dosage forms containing polymeric nanocapsules. The use of cellulose acetate (0.45 µm pore size), polycarbonate (0.05 µm pore size) and dialysis cellulose (12 kDa cut off) membranes was investigated. For this purpose, drug release studies from hydrogels containing clobetasol propionate-loaded lipid-core nanocapsules were carried out. A higher amount of clobetasol propionate reached the release medium using cellulose acetate and polycarbonate membranes, compared to the use of dialysis cellulose membrane. Photon correlation spectroscopy analyses showed an overlap between the particle size distributions of the receptor media from the release studies using cellulose acetate and polycarbonate membranes and the original lipid-core nanocapsules suspension diluted in the receptor medium. The presence of nanoparticles was further confirmed by transmission electron microscopy. On the other hand, particle size distribution observed in the receptor medium of release studies using dialysis cellulose membrane did not show particles at nanoscale. The overall results suggest that the dialysis cellulose membrane ensures that only released drug will reach the receptor compartment, and that it should be the first choice for in vitro drug release studies from semisolid dosage forms containing drug-loaded nanocapsules.
Keywords: Clobetasol propionate, dialysis bag, drug release studies, Franz diffusion cells, hydrogels, nanocapsules, synthetic membranes.
Graphical Abstract
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Books
Nanoscale Field Effect Transistors: Emerging Applications
Nanoelectronics Devices: Design, Materials, and Applications Part II
Nanoelectronics Devices: Design, Materials, and Applications (Part I)
Role of Nanotechnology in Cancer Therapy
Synthesis and Applications of Semiconductor Nanostructures
Pathways to Green Nanomaterials: Plants as Raw Materials, Reducing Agents and Hosts
Applications of Nanomaterials in Medical Procedures and Treatments
Synthesis of Nanomaterials
Nanobiotechnology: Principles and Applications
Bio-Inspired Nanotechnology
20