Abstract
Osteoporosis may cause bone fracture even under slight trauma. Osteoporotic fracture has become a major public health problem but until today, the treatments available are not satisfactory. Many pre-clinical testings on animals were done to find new agents that can be sourced from natural products and synthetic drugs for osteoporotic fracture healing. Animal models are more appropriate for fracture healing study than human subject due to several reasons including the ethical issues involved. The bones of rodents are similar to human in term of their morphological change and response to therapy. Small rodents such as rats and mice are suitable animal models for fracture healing studies as they have a similar bone remodeling system to human. To date, there is no specific guideline to carry out fracture healing studies in animal models for the evaluation of new agents. This paper highlights the protocols of various fracture and fixation methods for experimental osteoporotic fracture healing using rodent models.
Keywords: Bone fracture, fracture fixation, fracture healing, fracture method, osteoporosis, rodents.
Current Drug Targets
Title:Experimental Fracture Protocols in Assessments of Potential Agents for Osteoporotic Fracture Healing Using Rodent Models
Volume: 14 Issue: 14
Author(s): Nurul ‘Izzah Ibrahim, Sharlina Mohamad, Norazlina Mohamed and Ahmad Nazrun Shuid
Affiliation:
Keywords: Bone fracture, fracture fixation, fracture healing, fracture method, osteoporosis, rodents.
Abstract: Osteoporosis may cause bone fracture even under slight trauma. Osteoporotic fracture has become a major public health problem but until today, the treatments available are not satisfactory. Many pre-clinical testings on animals were done to find new agents that can be sourced from natural products and synthetic drugs for osteoporotic fracture healing. Animal models are more appropriate for fracture healing study than human subject due to several reasons including the ethical issues involved. The bones of rodents are similar to human in term of their morphological change and response to therapy. Small rodents such as rats and mice are suitable animal models for fracture healing studies as they have a similar bone remodeling system to human. To date, there is no specific guideline to carry out fracture healing studies in animal models for the evaluation of new agents. This paper highlights the protocols of various fracture and fixation methods for experimental osteoporotic fracture healing using rodent models.
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Cite this article as:
Ibrahim ‘Izzah Nurul, Mohamad Sharlina, Mohamed Norazlina and Shuid Nazrun Ahmad, Experimental Fracture Protocols in Assessments of Potential Agents for Osteoporotic Fracture Healing Using Rodent Models, Current Drug Targets 2013; 14 (14) . https://dx.doi.org/10.2174/1389450114666131216224003
DOI https://dx.doi.org/10.2174/1389450114666131216224003 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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