Abstract
Impact of mRNA processing and/or modifications has long been associated with gene expression regulation. Accumulating evidence shows alternative polyadenylation (APA), as an mRNA related process, to emerge as a widespread mechanism in gene expression regulation. Through selecting alternate (proximal or distal) polyadenylation signals on the 3’-UTR of pre-mRNAs, APA generates multiple transcript isoforms which may even create proteomic diversity. Depending on the use of proximal or distal polyadenylation sites, 3’-UTR lengths can vary in a tightly controlled manner in a spatial and temporal mode. Therefore, APA and its deregulation with potential consequences are highly relevant to normal and disease states. In this review, in light of recent findings in the literature, mechanism and types of APA and roles of APA in biological processes (i.e. proliferation, development, differentiation, and transformation) are discussed.
Keywords: Alternative polyadenylation, APA, microRNA, poly(A) site, 3’-UTR, posttranscriptional regulation.
MicroRNA
Title:Alternative Polyadenylation and Its Impact on Cellular Processes
Volume: 3 Issue: 1
Author(s): Hesna B. Akman and Ayse E. Erson-Bensan
Affiliation:
Keywords: Alternative polyadenylation, APA, microRNA, poly(A) site, 3’-UTR, posttranscriptional regulation.
Abstract: Impact of mRNA processing and/or modifications has long been associated with gene expression regulation. Accumulating evidence shows alternative polyadenylation (APA), as an mRNA related process, to emerge as a widespread mechanism in gene expression regulation. Through selecting alternate (proximal or distal) polyadenylation signals on the 3’-UTR of pre-mRNAs, APA generates multiple transcript isoforms which may even create proteomic diversity. Depending on the use of proximal or distal polyadenylation sites, 3’-UTR lengths can vary in a tightly controlled manner in a spatial and temporal mode. Therefore, APA and its deregulation with potential consequences are highly relevant to normal and disease states. In this review, in light of recent findings in the literature, mechanism and types of APA and roles of APA in biological processes (i.e. proliferation, development, differentiation, and transformation) are discussed.
Export Options
About this article
Cite this article as:
B. Akman Hesna and E. Erson-Bensan Ayse, Alternative Polyadenylation and Its Impact on Cellular Processes, MicroRNA 2014; 3 (1) . https://dx.doi.org/10.2174/2211536602666131210001152
DOI https://dx.doi.org/10.2174/2211536602666131210001152 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Molecular Targeting of Drug Delivery Systems to Cancer
Current Drug Targets The Challenge of Exploiting ABCG2 in the Clinic
Current Pharmaceutical Biotechnology Sigma-2 Receptor as a Potential Drug Target
Current Medicinal Chemistry Potential of Modulating Wnt Signaling Pathway Toward the Development of Bone Anabolic Agent
Current Molecular Pharmacology Doxycycline in Mitochondrial Mediated Pathway of Apoptosis: A Systematic Review
Anti-Cancer Agents in Medicinal Chemistry Mitochondrial Therapeutics for Cardioprotection
Current Pharmaceutical Design Targeting Invasion Induction as a Therapeutic Strategy for the Treatment of Cancer
Current Cancer Drug Targets Modified Polysaccharides as Versatile Materials in Controlled Delivery of Antidegenerative Agents
Current Pharmaceutical Design Tumor Specific Novel Taxoid-Monoclonal Antibody Conjugates
Current Medicinal Chemistry Antidepressants and Neuroinflammation: Can Antidepressants Calm Glial Rage Down?
Mini-Reviews in Medicinal Chemistry Review on Triggered Liposomal Drug Delivery with a Focus on Ultrasound
Current Cancer Drug Targets Computational Bioactivity Analysis and Bioisosteric Investigation of the Approved Breast Cancer Drugs Proposed New Design Drug Compounds: Increased Bioactivity Coming with Silicon and Boron
Letters in Drug Design & Discovery Interaction of ABC Multidrug Transporters with Anticancer Protein Kinase Inhibitors: Substrates and/or Inhibitors?
Current Cancer Drug Targets Head and Neck Cancer Treatments through Chemotherapy to Magnetic Systems: Perspectives and Challenges
Current Radiopharmaceuticals Proteinase-Activated Receptor 2 (PAR2): A Challenging New Target for Treatment of Vascular Diseases
Current Pharmaceutical Design Resveratrol and Prostate Cancer: The Power of Phytochemicals
Current Medicinal Chemistry Life Under Stress: The Probiotic Stress Response and How it may be Manipulated
Current Pharmaceutical Design A Review on Subcutaneous Veins Localization Using Imaging Techniques
Current Medical Imaging Role of ABC Transporters in the Chemoresistance of Human Gliomas
Current Cancer Drug Targets Management of Incidental Findings in the Era of Next-generation Sequencing
Current Genomics