Abstract
Nesfatin-1, derived from the nucleobindin-2 gene product, is expressed in neurons located in brain centers known to be important in the central regulation of both cardiovascular function and fluid and electrolyte homeostasis. In fact the peptide colocalizes in those neurons with an impressive list of neuropeptides and neurotransmitters known to be important in the regulation of thirst, appetite and central autonomic control. We and others have demonstrated potent sympatho-stimulatory actions of nesfatin-1 in brain and the potential physiologic relevance of those effects. In addition, although nesfatin-1 was originally described as a peptide with potent anorexigenic actions in brain, effects corroborated by several groups, it is possible that the anorexigenic actions of nesfatin-1 are secondary to a primary action to reduce thirst. Progress in unraveling the importance of endogenous nesfatin-1 in cardiovascular function, or fluid and electrolyte homeostasis, has been limited due to the to date unavailability of nesfatin-1 antagonists and the fact that the receptor for nesfatin-1 remains unidentified.
Keywords: Arterial pressure, sympathetic nervous system, hypothalamus, medulla, thirst, appetite.
Current Pharmaceutical Design
Title:Cardiovascular and Antidipsogenic Effects of Nesfatin-1
Volume: 19 Issue: 39
Author(s): Gina L.C. Yosten and Willis K. Samson
Affiliation:
Keywords: Arterial pressure, sympathetic nervous system, hypothalamus, medulla, thirst, appetite.
Abstract: Nesfatin-1, derived from the nucleobindin-2 gene product, is expressed in neurons located in brain centers known to be important in the central regulation of both cardiovascular function and fluid and electrolyte homeostasis. In fact the peptide colocalizes in those neurons with an impressive list of neuropeptides and neurotransmitters known to be important in the regulation of thirst, appetite and central autonomic control. We and others have demonstrated potent sympatho-stimulatory actions of nesfatin-1 in brain and the potential physiologic relevance of those effects. In addition, although nesfatin-1 was originally described as a peptide with potent anorexigenic actions in brain, effects corroborated by several groups, it is possible that the anorexigenic actions of nesfatin-1 are secondary to a primary action to reduce thirst. Progress in unraveling the importance of endogenous nesfatin-1 in cardiovascular function, or fluid and electrolyte homeostasis, has been limited due to the to date unavailability of nesfatin-1 antagonists and the fact that the receptor for nesfatin-1 remains unidentified.
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Cite this article as:
Yosten L.C. Gina and Samson K. Willis, Cardiovascular and Antidipsogenic Effects of Nesfatin-1, Current Pharmaceutical Design 2013; 19 (39) . https://dx.doi.org/10.2174/138161281939131127142720
DOI https://dx.doi.org/10.2174/138161281939131127142720 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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