Abstract
The syntheses of hydrazone derivatives with thiazole and triazole rings were described. The target compounds 7a-j and 8a-g with the hydrazine based structure containing thiazole and triazole rings were synthesized respectively through the reactions of α-bromomethylpyrazole ketone 3 with arylethanone thiosemicarbazones 5a-j and the reactions of pyrazol thiosemicarbazone 4 with α-bromomethyl aryl ketones 6a-g under reflux condition without catalyst. Furthermore, an eco-friendly convenient method for the synthesis of compounds 8a-g was developed using one-pot route. The target compounds were tested for preliminary bioactivities by using H2O2-induced PC 12 cells with oxidative injury.
Keywords: 1, 2, 3-Triazole, thiazole, hydrazone, synthesis, one-pot reaction, bioactivity.
Letters in Organic Chemistry
Title:An Efficient Synthesis of Some New Hydrazone Derivatives Containing 1,2,3-Triazole and Thiazole
Volume: 10 Issue: 10
Author(s): Keyume Ablajan, Wang Liju and Anagu Tuoheti
Affiliation:
Keywords: 1, 2, 3-Triazole, thiazole, hydrazone, synthesis, one-pot reaction, bioactivity.
Abstract: The syntheses of hydrazone derivatives with thiazole and triazole rings were described. The target compounds 7a-j and 8a-g with the hydrazine based structure containing thiazole and triazole rings were synthesized respectively through the reactions of α-bromomethylpyrazole ketone 3 with arylethanone thiosemicarbazones 5a-j and the reactions of pyrazol thiosemicarbazone 4 with α-bromomethyl aryl ketones 6a-g under reflux condition without catalyst. Furthermore, an eco-friendly convenient method for the synthesis of compounds 8a-g was developed using one-pot route. The target compounds were tested for preliminary bioactivities by using H2O2-induced PC 12 cells with oxidative injury.
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Cite this article as:
Ablajan Keyume, Liju Wang and Tuoheti Anagu, An Efficient Synthesis of Some New Hydrazone Derivatives Containing 1,2,3-Triazole and Thiazole, Letters in Organic Chemistry 2013; 10 (10) . https://dx.doi.org/10.2174/157017861010131126115715
DOI https://dx.doi.org/10.2174/157017861010131126115715 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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