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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis of Oxygenated Chalcones with Anti-Staphylococcal Activity

Author(s): Luciana Dalla-Vechia, Cíntia Janine Kiekow, Ivana Correa Ramos Leal, Katia Regina Netto Dos Santos, Simone Cristina Baggio Gnoatto, Hugo Verli, Rodrigo Octavio Mendonca Alves de Souza and Grace Gosmann

Volume 11, Issue 5, 2014

Page: [525 - 530] Pages: 6

DOI: 10.2174/1570180810666131125221032

Price: $65

Abstract

Gram-positive bacteria are the most common cause of skin infection in hospitalized patients, with Staphylococcus aureus being the principal pathogen responsible for deaths. A series of poly-oxygenated chalcones was synthesized and assayed for anti-staphylococcal activity. Hydroxylated chalcones were more effective in the inhibition of microbial growth than methoxylated analogues. The compound 3’,5’,4-trihydroxychalcone is the most promising compound among those evaluated, showing a much broader antimicrobial spectrum than oxacillin and a MIC of 64 µg/ml to a multidrug- resistant hospital clinical strain of S. aureus.

Keywords: Antimicrobial, Aldol condensation, Chalcone, Phenolic compound.

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