Synthesis and In Vivo Hepatoprotective Activity of Some Novel Andrographolide Derivatives

Title:Synthesis and In Vivo Hepatoprotective Activity of Some Novel Andrographolide Derivatives

Volume: 11 Issue: 5

Author(s): Chunlei Tang, Guolong Gu, Baowei Yang, Xuekun Wang, Hai Qian, Wenlong Huang, Xiaoyun Zhu and Jing Li

Affiliation:

Keywords: Andrographolide, Combination-principle, Derivatives, Hepatoprotective, Natural products, Synthesis.

Abstract: In this study, combination-principle was reported to improve the hepatoprotective activity of andrographolide. Ten andrographolide derivatives were synthesized and evaluated for in vivo hepatoprotective activity in CCl₄-induced liver injury mice. The pharmacological results revealed that 6 derivatives exhibited significant hepatoprotective activity. The most promising compound 6b significantly improved liver enzymes (ALT and AST) activity as compared with andrographolide, with high potency to be a new lead.

Cite this article as:

Tang Chunlei, Gu Guolong, Yang Baowei, Wang Xuekun, Qian Hai, Huang Wenlong, Zhu Xiaoyun and Li Jing, Synthesis and In Vivo Hepatoprotective Activity of Some Novel Andrographolide Derivatives, Letters in Drug Design & Discovery 2014; 11 (5) . https://dx.doi.org/10.2174/1570180810666131123002409