Abstract
As a part of our ongoing studies in developing new derivatives as dual antibacterial/antifungal agents, we describe the synthesis of novel amino substituted benzofuroxan derivatives. These compounds were tested for their antifungal activity against various strains. It is shown that their antimicrobial and antifungal activities depend on the structure of the amino moiety, on the position and on the nature of the substituents of the benzofuroxan ring. They displayed good bacteriostatic and fungistatic activities comparable to those of reference drugs. The more active benzofuroxan derivatives have been studied intraperitoneally in mice to get a first estimation of their toxicity. Preliminary results have also shown that some derivatives are able to inhibit enzymes such as GDH (glucose dehydrogenase).
Keywords: Bacteriostatic activity, Fungistatic activity, Intraperitoneal introduction, Amine substitution, Benzofuroxan.
Letters in Drug Design & Discovery
Title:The Study of the Biological Activity of Amino-Substituted Benzofuroxans
Volume: 11 Issue: 4
Author(s): Elena A. Chugunova, Alexandra D. Voloshina, Rezeda E. Mukhamatdinova, Igor V. Serkov, Alexey N. Proshin, Elmira M. Gibadullina, Alexander R. Burilov, Natalia V. Kulik, Vladimir V. Zobov, Dmitry B. Krivolapov, Alexey B. Dobrynin and Regis Goumont
Affiliation:
Keywords: Bacteriostatic activity, Fungistatic activity, Intraperitoneal introduction, Amine substitution, Benzofuroxan.
Abstract: As a part of our ongoing studies in developing new derivatives as dual antibacterial/antifungal agents, we describe the synthesis of novel amino substituted benzofuroxan derivatives. These compounds were tested for their antifungal activity against various strains. It is shown that their antimicrobial and antifungal activities depend on the structure of the amino moiety, on the position and on the nature of the substituents of the benzofuroxan ring. They displayed good bacteriostatic and fungistatic activities comparable to those of reference drugs. The more active benzofuroxan derivatives have been studied intraperitoneally in mice to get a first estimation of their toxicity. Preliminary results have also shown that some derivatives are able to inhibit enzymes such as GDH (glucose dehydrogenase).
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Chugunova A. Elena, Voloshina D. Alexandra, Mukhamatdinova E. Rezeda, Serkov V. Igor, Proshin N. Alexey, Gibadullina M. Elmira, Burilov R. Alexander, Kulik V. Natalia, Zobov V. Vladimir, Krivolapov B. Dmitry, Dobrynin B. Alexey and Goumont Regis, The Study of the Biological Activity of Amino-Substituted Benzofuroxans, Letters in Drug Design & Discovery 2014; 11 (4) . https://dx.doi.org/10.2174/1570180810666131122010403
DOI https://dx.doi.org/10.2174/1570180810666131122010403 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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