Abstract
Peptide-based nanomaterials are widely used as nanocarriers for catalysis, drug delivery, and gene delivery. In this paper, we designed and synthesized the amphiphilic tripeptides through solution phase synthesis. The tripeptides were purified by column chromatography and the molecular structures were confirmed by 1H NMR and TOF-MS. The tripeptides could self-assemble into spherical nanoparticles in aqueous media with a low critical aggregation concentration. The size and morphology of the nanoparticles were performed by dynamic light scattering, scanning electron microscopy and transmission electron microscope. The peptide-based nanoparticles were used as biocompatible nanocarriers for encapsulating hydrophobic doxorubicin (DOX) to achieve controlled release. The CCK-8 assay indicated that the peptide-based nanocarriers could enhance cellular uptake and drug efficacy of DOX to A549 tumor cell line. These results showed that the self-assembly of amphiphilic tripeptides provided a facile strategy to fabricate nanoparticles for anti-tumor drug delivery.
Keywords: Amphiphilic tripeptide, controlled release, cytotoxicity, drug delivery, nanoparticles, self-assembly.
Protein & Peptide Letters
Title:Self-assembly of Amphiphilic Tripeptides into Nanoparticles for Drug Delivery
Volume: 21 Issue: 2
Author(s): Zhaoxu Tu, Xianghui Xu, Yeting Jian, Dan Zhong, Bin He and Zhongwei Gu
Affiliation:
Keywords: Amphiphilic tripeptide, controlled release, cytotoxicity, drug delivery, nanoparticles, self-assembly.
Abstract: Peptide-based nanomaterials are widely used as nanocarriers for catalysis, drug delivery, and gene delivery. In this paper, we designed and synthesized the amphiphilic tripeptides through solution phase synthesis. The tripeptides were purified by column chromatography and the molecular structures were confirmed by 1H NMR and TOF-MS. The tripeptides could self-assemble into spherical nanoparticles in aqueous media with a low critical aggregation concentration. The size and morphology of the nanoparticles were performed by dynamic light scattering, scanning electron microscopy and transmission electron microscope. The peptide-based nanoparticles were used as biocompatible nanocarriers for encapsulating hydrophobic doxorubicin (DOX) to achieve controlled release. The CCK-8 assay indicated that the peptide-based nanocarriers could enhance cellular uptake and drug efficacy of DOX to A549 tumor cell line. These results showed that the self-assembly of amphiphilic tripeptides provided a facile strategy to fabricate nanoparticles for anti-tumor drug delivery.
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Cite this article as:
Tu Zhaoxu, Xu Xianghui, Jian Yeting, Zhong Dan, He Bin and Gu Zhongwei, Self-assembly of Amphiphilic Tripeptides into Nanoparticles for Drug Delivery, Protein & Peptide Letters 2014; 21 (2) . https://dx.doi.org/10.2174/09298665113206660117
DOI https://dx.doi.org/10.2174/09298665113206660117 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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