Generic placeholder image

Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Review Article

Regulation and Function of Antimicrobial Peptides in Immunity and Diseases of the Lung

Author(s): Frederik Seiler, Philipp Moritz Lepper, Robert Bals and Christoph Beisswenger

Volume 21, Issue 4, 2014

Page: [341 - 351] Pages: 11

DOI: 10.2174/09298665113206660100

Price: $65

Abstract

Cationic antimicrobial peptides (AMPs) are among the best studied antimicrobial factors expressed in the respiratory tract. AMPs are released by epithelial cells and immune cells into the airway surface liquid covering the epithelial surfaces of the lung where they act as endogenous antibiotics. Plenty of studies showed that AMPs possess additional, often immunomodulatory functions besides their antimicrobial activities. AMPs are chemotactic for immune cells and modulate cellular mechanisms, such as proliferation of epithelial cells, epithelial regeneration, and angiogenesis. The expression and activity of AMPs are impacted by lung diseases and AMPs can have adverse effects in lung diseases. In this review, we discuss the regulation and functions of AMPs in host defense and respiratory tract diseases.

Keywords: Antimicrobial peptide, Cathelicidin, COPD, Cystic fibrosis, Defensin, Lung disease, Pneumonia.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy