Abstract
Antiepileptic drugs can cause some adverse effects ranging from mild to acute and serious ones. The inducing properties of some of them may result in vitamin D, vitamin K and estrogens catabolism and thus risk of fractures or efflux transport overexpression at the blood brain barrier and consequently lack of effect at the action site. Some are responsible for the formation of reactive metabolites, such as arene oxides or atropaldehyde intermediates, in skin, liver and other organs, causing hypersensitivity reactions or can enhance a commonly minor metabolic pathway increasing the formation of toxic metabolites. Drug-induced myopia and other visual problems have also been described with the use of antiepileptic agents. A pharmacological insight of the possible concentration-dependent mechanism involved in these reactions is given in this review and in some cases some preventive measures to revert them.
Keywords: Adverse drugs reactions- Concentrations-dependent mechanisms-Antiepileptic drugs
Current Pharmaceutical Design
Title:Concentration-Dependent Mechanisms of Adverse Drug Reactions in Epilepsy
Volume: 19 Issue: 38
Author(s): Marta Vázquez, Pietro Fagiolino and Eduardo L. Mariño
Affiliation:
Keywords: Adverse drugs reactions- Concentrations-dependent mechanisms-Antiepileptic drugs
Abstract: Antiepileptic drugs can cause some adverse effects ranging from mild to acute and serious ones. The inducing properties of some of them may result in vitamin D, vitamin K and estrogens catabolism and thus risk of fractures or efflux transport overexpression at the blood brain barrier and consequently lack of effect at the action site. Some are responsible for the formation of reactive metabolites, such as arene oxides or atropaldehyde intermediates, in skin, liver and other organs, causing hypersensitivity reactions or can enhance a commonly minor metabolic pathway increasing the formation of toxic metabolites. Drug-induced myopia and other visual problems have also been described with the use of antiepileptic agents. A pharmacological insight of the possible concentration-dependent mechanism involved in these reactions is given in this review and in some cases some preventive measures to revert them.
Export Options
About this article
Cite this article as:
Vázquez Marta, Fagiolino Pietro and L. Mariño Eduardo, Concentration-Dependent Mechanisms of Adverse Drug Reactions in Epilepsy, Current Pharmaceutical Design 2013; 19 (38) . https://dx.doi.org/10.2174/1381612811319380012
DOI https://dx.doi.org/10.2174/1381612811319380012 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cancer Nanotechnology: Emerging Role of Gold Nanoconjugates
Anti-Cancer Agents in Medicinal Chemistry Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer’s Disease
Current Alzheimer Research Clinical Profile of Mortality among Chronic Schizophrenic Patients: A Local Pilot Survey in Iran
Current Psychiatry Research and Reviews The Synthesis and Evaluation of Novel Lactate Dehydrogenase Nanobioconjugates
Current Nanoscience Novel Pharmacological Targets From Indian Cone Snails
Mini-Reviews in Medicinal Chemistry Nanoparticles as a Carrier System for Drug Delivery Across Blood Brain Barrier
Current Drug Metabolism Astroglial Connexins in Neurological and Neuropsychological Disorders and Radiation Exposure
Current Medicinal Chemistry Natural Antioxidants: Therapeutic Prospects for Cancer and Neurological Diseases
Mini-Reviews in Medicinal Chemistry Characterization of the Early CNS Stress Biomarkers and Profiles Associated with Neuropsychiatric Diseases
Current Genomics Metalloprotein Inhibitors for the Treatment of Human Diseases
Current Topics in Medicinal Chemistry Concentration-Dependent Bimodal Effect of Specific 18 kDa Translocator Protein (TSPO) Ligands on Cell Death Processes Induced by Ammonium Chloride: Potential Implications for Neuropathological Effects Due to Hyperammonemia
CNS & Neurological Disorders - Drug Targets Unique Medicinal Properties of Withania somnifera: Phytochemical Constituents and Protein Component
Current Pharmaceutical Design Ligand based Drug Design of New Heterocyclic Imines of GABA Analogues: A Molecular Docking Approach for the Discovery of New GABA-AT Inhibitors
Central Nervous System Agents in Medicinal Chemistry Neuroprotective Methodologies of Co-Enzyme Q10 Mediated Brain Hemorrhagic Treatment: Clinical and Pre-Clinical Findings
CNS & Neurological Disorders - Drug Targets Parallel Computing for Brain Simulation
Current Topics in Medicinal Chemistry Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update
Current Medicinal Chemistry Vasculogenic and Angiogenic Pathways in Moyamoya Disease
Current Medicinal Chemistry Anti-Inflammatory Immunotherapy for Multiple Sclerosis/Experimental Autoimmune Encephalomyelitis (EAE) Disease
Current Medicinal Chemistry Design and Synthesis of New Selective P-gp Substrates and Inhibitors
Current Pharmaceutical Design 3D-QSAR Study of Some Heterocyclic Sulfonamide Analogs as hCAII Inhibitors
Letters in Drug Design & Discovery