Abstract
A target-based approach has been used to develop novel drugs in many therapeutic fields. However, this approach remains suboptimal for drug discovery in brain disorders because the target identification in a brain disorder requires a hierarchical integration from in vitro cellular and functional tissue studies to animal models that sustain neuronal and glial complexity. Although glial cells comprise over half of the brain and play important roles in brain function and disease, the intracellular signaling of glial cells remains essentially unexplored. This is because the lack of optimal strategy to selectively activate or deactivate glial signaling has made it difficult to study glial roles. The recent development of approaches using mouse models and enabling the selective activation of cell signaling could be used to assess the role of glial cells in physiology and disease. This review presents how glial G- protein signaling contributes to brain disorders and how the role of glia is investigated.
Keywords: Gq-DREADD (designer receptor exclusively activated by designer drug), glial cells, G-protein coupled receptors, proteomics, neuronal disorder, tissue culture.
CNS & Neurological Disorders - Drug Targets
Title:Recent Approaches for Studying the Role of Glia
Volume: 13 Issue: 1
Author(s): Seyeon Park
Affiliation:
Keywords: Gq-DREADD (designer receptor exclusively activated by designer drug), glial cells, G-protein coupled receptors, proteomics, neuronal disorder, tissue culture.
Abstract: A target-based approach has been used to develop novel drugs in many therapeutic fields. However, this approach remains suboptimal for drug discovery in brain disorders because the target identification in a brain disorder requires a hierarchical integration from in vitro cellular and functional tissue studies to animal models that sustain neuronal and glial complexity. Although glial cells comprise over half of the brain and play important roles in brain function and disease, the intracellular signaling of glial cells remains essentially unexplored. This is because the lack of optimal strategy to selectively activate or deactivate glial signaling has made it difficult to study glial roles. The recent development of approaches using mouse models and enabling the selective activation of cell signaling could be used to assess the role of glial cells in physiology and disease. This review presents how glial G- protein signaling contributes to brain disorders and how the role of glia is investigated.
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Cite this article as:
Park Seyeon, Recent Approaches for Studying the Role of Glia, CNS & Neurological Disorders - Drug Targets 2014; 13 (1) . https://dx.doi.org/10.2174/18715273113126660191
DOI https://dx.doi.org/10.2174/18715273113126660191 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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