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Current Bioinformatics

Editor-in-Chief

ISSN (Print): 1574-8936
ISSN (Online): 2212-392X

A New Approach for Identifying Protein-Coding Regions by Combining Chirp z and Wavelet Transform.

Author(s): Suping Deng, Liyun Yuan, Kanyan Feng, Guohui Ding and Yixue Li

Volume 8, Issue 5, 2013

Page: [557 - 563] Pages: 7

DOI: 10.2174/1574893611308050006

Price: $65

Abstract

Identifying protein coding regions of DNA sequences is an important step in gene annotation. It is well-known that the protein coding regions of most genomic sequences exhibit a period-3 pattern due to non-uniform distribution of codons. In order to identify protein coding regions more efficiently, a new identification approach was proposed by combining chirp z transform and wavelet transform based on period-3 property. The identification method was applied to 17 DNA sequences of different organisms and achieved a high sensitivity (>80%) in all sequences. Demanding no prior training sets, the approach is fast and could potentially be used widely and conveniently.

Keywords: Chirp z transform, fourier transform, identification, period-3 pattern, protein-coding regions, wavelet transform.


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