Abstract
Physeal injuries may lead to the formation of a bone bridge resulting in limb length discrepancies and angular deformity in children. Current treatment of physeal injuries may be challenging. A number of strategies have been used to repair physeal defects with varying results. Biological regeneration using stem cells is therefore an attractive potential future option to repair physeal defects. Preclinical animal studies using stem cells have shown mixed results. Studies have investigated the use of various scaffolds including chitin, collagen and gelfoam. Significant progress has been made in discovering appropriate growth factors such as transforming growth factor (TGF-), insulin-like growth factor (IGF-1), bone morphogenetic proteins (BMPs) and fibroblast growth factor (FGF-2) that could induce physeal repair and be used in combination with stem cell therapy. Advances have been made in the use of gene therapy to maintain sustainable delivery of growth factors to injury sites. This review discusses the current stem cell therapy available to repair physeal injuries.
Keywords: Cartilage, chondrocytes, differentiation, growth plate, physis, scaffolds, stem cells.
Current Stem Cell Research & Therapy
Title:Applications of Stem Cell Therapy for Physeal Injuries.
Volume: 8 Issue: 6
Author(s): Anita Sanghani, Mukai Chimutengwende-Gordon, Adetola Adesida and Wasim Khan
Affiliation:
Keywords: Cartilage, chondrocytes, differentiation, growth plate, physis, scaffolds, stem cells.
Abstract: Physeal injuries may lead to the formation of a bone bridge resulting in limb length discrepancies and angular deformity in children. Current treatment of physeal injuries may be challenging. A number of strategies have been used to repair physeal defects with varying results. Biological regeneration using stem cells is therefore an attractive potential future option to repair physeal defects. Preclinical animal studies using stem cells have shown mixed results. Studies have investigated the use of various scaffolds including chitin, collagen and gelfoam. Significant progress has been made in discovering appropriate growth factors such as transforming growth factor (TGF-), insulin-like growth factor (IGF-1), bone morphogenetic proteins (BMPs) and fibroblast growth factor (FGF-2) that could induce physeal repair and be used in combination with stem cell therapy. Advances have been made in the use of gene therapy to maintain sustainable delivery of growth factors to injury sites. This review discusses the current stem cell therapy available to repair physeal injuries.
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Cite this article as:
Sanghani Anita, Chimutengwende-Gordon Mukai, Adesida Adetola and Khan Wasim, Applications of Stem Cell Therapy for Physeal Injuries., Current Stem Cell Research & Therapy 2013; 8 (6) . https://dx.doi.org/10.2174/1574888X1130800063
DOI https://dx.doi.org/10.2174/1574888X1130800063 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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