Abstract
For several decades, interest in pyrrole derivatives increased due to their pharmaceutical importance, such as antimicrobial, anti-inflammatory, analgesic, anti-tumor, anti-epileptic, anti-viral, anti-hypertensive, and anti-diabetic agents. These huge therapeutic applications have motivated new efforts in searching for novel derivatives with improved biological activity and diverse applications in pharmaceutical industry. Motivated by the importance of this system, and in continuation of our research efforts, we have tried to highlight aspects reported on the chemistry and biological activity of pyrrole and its fused derivatives during the past years (till 2012).
Keywords: Pyrrole, fused pyrrole, pyrrolopyrimidine, synthesis, biological activities and drugs.
Mini-Reviews in Organic Chemistry
Title:Pyrroles and Fused Pyrroles: Synthesis and Therapeutic Activities
Volume: 11 Issue: 4
Author(s): Mosaad S. Mohamed and Samar S. Fathallah
Affiliation:
Keywords: Pyrrole, fused pyrrole, pyrrolopyrimidine, synthesis, biological activities and drugs.
Abstract: For several decades, interest in pyrrole derivatives increased due to their pharmaceutical importance, such as antimicrobial, anti-inflammatory, analgesic, anti-tumor, anti-epileptic, anti-viral, anti-hypertensive, and anti-diabetic agents. These huge therapeutic applications have motivated new efforts in searching for novel derivatives with improved biological activity and diverse applications in pharmaceutical industry. Motivated by the importance of this system, and in continuation of our research efforts, we have tried to highlight aspects reported on the chemistry and biological activity of pyrrole and its fused derivatives during the past years (till 2012).
Export Options
About this article
Cite this article as:
Mohamed S. Mosaad and Fathallah S. Samar, Pyrroles and Fused Pyrroles: Synthesis and Therapeutic Activities, Mini-Reviews in Organic Chemistry 2014; 11 (4) . https://dx.doi.org/10.2174/1570193X113106660018
DOI https://dx.doi.org/10.2174/1570193X113106660018 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Target-based Anti-angiogenic Therapy in Breast Cancer
Current Pharmaceutical Design Subject Index To Volume 7
Current Protein & Peptide Science Hypotensive Effect of Hydroalcoholic Ziziphus jujuba Extract on Normotensive Rats
Current Nutrition & Food Science Management of Hypertension in Patients with Chronic Kidney Disease in Asia
Current Hypertension Reviews Thromboxane A<sub>2</sub> Receptor Polymorphism in Association with Cerebral Infarction and its Regulation on Platelet Function
Current Neurovascular Research The Role of Genetic Polymorphism in the Formation of Arterial Hypertension, Type 2 Diabetes and their Comorbidity
Current Pharmaceutical Design Hypopituitarism in Neurocritical Patients: A Case Report
Endocrine, Metabolic & Immune Disorders - Drug Targets Meet Our Editor
Current Clinical Pharmacology Development of a Triggered Nocturnal Blood Pressure Monitoring which Detects Nighttime Blood Pressure Surges in Sleep Apnea Syndrome
Current Hypertension Reviews Molecules to Selectively Target Receptors for Treatment of Pain and Neurogenic Inflammation
Recent Patents on Inflammation & Allergy Drug Discovery Young Stroke Patients Treated with Intravenous Thrombolysis have a More Favorable Outcome and Mortality Compared with Older Patients
Current Neurovascular Research The Association Between HIV/AIDS During Pregnancy and Fetal Growth Parameters in Florida: A Population Based Study
Current HIV Research Latest Therapeutic Novelties and Patents in Pulmonary Hypertension
Recent Patents on Cardiovascular Drug Discovery Amiodarone-Induced SIADH: Two Cases Report
Endocrine, Metabolic & Immune Disorders - Drug Targets Editorial [Hot Topic: Current Drug Targets for the Critically Ill COPD Patient (Guest Editors: Demosthenes Makris and Epaminondas Zakynthinos)]
Current Drug Targets Treatment of Chronic Hepatitis B: From Research to Clinical Practice Via the Consensus Conferences
Current Pharmaceutical Design Metabolic and Cardiovascular Ageing Indices in Relation to Glycated Haemoglobin in Healthy and Diabetic Subjects
Current Aging Science New Pharmacological Approaches to the Prevention of Myocardial Ischemia- Reperfusion Injury
Current Drug Targets Editorial (Thematic Issue: Angiogenesis in the Development of Cardiovascular Diseases)
Current Angiogenesis (Discontinued) Sex Differences in Clinical Outcomes of Patients with Stable Coronary Artery Disease after Percutaneous Coronary Intervention
Current Pharmaceutical Design