Abstract
Recent years have witnessed an unprecedented progress in biological applications of metal coordination compounds of biologically active ligands because of their key role in clinical therapy. Transition metals are particularly suitable for this purpose because they can adopt a wide variety of coordination numbers, geometries and oxidation states in comparison with other main group elements. One of the characteristics of metals is their potential to undergo redox processes, as determined by their redox potentials. Especially, transition metal ions are usually able to switch between several oxidation states. Due to the redox activity of metals and, therefore, a possible disturbance of the sensitive cellular redox homeostasis, a tight regulation of the metal and redox balance is crucial for health. On the other hand, over production of activated oxygen species, generated by normal metabolic process, is considered to be the main contributor to oxidative damages to biomolecules such as DNA, lipids and proteins, thus accelerating cancer, aging, inflammation, cardiovascular and neurodegenerative diseases. The potential value of antioxidants has already prompted investigators to search for the cooperative effects of metal complexes and natural compounds for improving antioxidant activity. Depending on their structure and on the source of the oxidative stress, metal complexes might act as antioxidants or prooxidants. The current review provides insight into the interaction between the reactive oxygen species and the transition metals and their complexes. It will focus on a novel approach to design synthetic antioxidant metal-based compounds and to study their activities in the oxidation processes. This work underlines some important features for the research on metal complexes of biologically active ligands as antioxidants, and supports future evaluation of some of these compounds as possible therapeutic agents.
Keywords: Metal complexes, biologically active ligands, antioxidants
Current Medicinal Chemistry
Title:Metal Complexes of Biologically Active Ligands as Potential Antioxidants
Volume: 20 Issue: 36
Author(s): Irena Kostova and Stefan Balkansky
Affiliation:
Keywords: Metal complexes, biologically active ligands, antioxidants
Abstract: Recent years have witnessed an unprecedented progress in biological applications of metal coordination compounds of biologically active ligands because of their key role in clinical therapy. Transition metals are particularly suitable for this purpose because they can adopt a wide variety of coordination numbers, geometries and oxidation states in comparison with other main group elements. One of the characteristics of metals is their potential to undergo redox processes, as determined by their redox potentials. Especially, transition metal ions are usually able to switch between several oxidation states. Due to the redox activity of metals and, therefore, a possible disturbance of the sensitive cellular redox homeostasis, a tight regulation of the metal and redox balance is crucial for health. On the other hand, over production of activated oxygen species, generated by normal metabolic process, is considered to be the main contributor to oxidative damages to biomolecules such as DNA, lipids and proteins, thus accelerating cancer, aging, inflammation, cardiovascular and neurodegenerative diseases. The potential value of antioxidants has already prompted investigators to search for the cooperative effects of metal complexes and natural compounds for improving antioxidant activity. Depending on their structure and on the source of the oxidative stress, metal complexes might act as antioxidants or prooxidants. The current review provides insight into the interaction between the reactive oxygen species and the transition metals and their complexes. It will focus on a novel approach to design synthetic antioxidant metal-based compounds and to study their activities in the oxidation processes. This work underlines some important features for the research on metal complexes of biologically active ligands as antioxidants, and supports future evaluation of some of these compounds as possible therapeutic agents.
Export Options
About this article
Cite this article as:
Kostova Irena and Balkansky Stefan, Metal Complexes of Biologically Active Ligands as Potential Antioxidants, Current Medicinal Chemistry 2013; 20 (36) . https://dx.doi.org/10.2174/09298673113206660288
DOI https://dx.doi.org/10.2174/09298673113206660288 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Biomarkers for Early Detection of Colitis-associated Colorectal Cancer - Current Concepts, Future Trends
Current Drug Targets Patent Annotations
Recent Patents on CNS Drug Discovery (Discontinued) Youtube as a Source of Patients’ and Specialists’ Information on Hemorrhoids and Hemorrhoid Surgery
Reviews on Recent Clinical Trials Drug Delivery Systems for Local Anesthetics
Recent Patents on Drug Delivery & Formulation Industrial Chemicals and Acute Lung injury with a Focus on Exposure Scenarios
Current Respiratory Medicine Reviews The Struggle with Rheumatism through Dracunculus vulgaris Schott: In the Light of Ethnobotanical Information
Current Molecular Pharmacology Novel Oral Anticoagulants: Recommendations for Patient Evaluation, Treatment Initiation, Follow-up and Perioperative Management
Cardiovascular & Hematological Disorders-Drug Targets Review on Pharmacological and Phytochemical Prospects of Traditional Medicinal Plant: <i>Persicaria hydropiper</i> (Smartweed)
Current Topics in Medicinal Chemistry Is Intake of Flavonoid-Based Food Supplements During Pregnancy Safe for the Developing Child? A Literature Review
Current Drug Targets Cardioprotective Effects of Indian Gooseberry (Emblica officinalis Gaertn) and its Phytochemicals: A Review
Current Nutrition & Food Science Merging Traditional Chinese Medicine with Modern Drug Discovery Technologies to Find Novel Drugs and Functional Foods
Current Drug Discovery Technologies Anatomy, Physiology and Pathophysiology of Haemorrhoids
Reviews on Recent Clinical Trials Refractory Cough as a Remote Manifestation of Retroperitoneal Liposarcoma
Current Cancer Therapy Reviews A Meta-Analysis of Proteomic Blood Markers of Colorectal Cancer
Current Medicinal Chemistry A Critical Review on the Unexplored Therapeutic Treasure of Himalayan Ayurvedic Drug Daruharidra (<i>Berberis Aristata</i>)
Current Traditional Medicine Antiproliferative Activity of <i>Cissus quadrangularis</i> L. Extract Against Human Cervical Cancer Cells: In Vitro and In Silico Analysis
Anti-Cancer Agents in Medicinal Chemistry Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach
Current Drug Targets Therapeutic Potential of Natural Products from Terrestrial Plants as TNF-α Antagonist
Current Topics in Medicinal Chemistry Do We Have Another Option to Treat Bleeding Hemorrhoids? The Emborrhoid Technique: Experience in 16 Patients
Reviews on Recent Clinical Trials Outpatient Treatment of Hemorrhoidal Disease: The Alternative Way to Treat Hemorrhoidal Disease in a Simple, Safe and Effective Manner
Reviews on Recent Clinical Trials