Abstract
Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer’s disease. Recent studies provide inkling for the use of IDE as a potential target hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes mellitus and Alzheimer’s disease and the approaches that make IDE a potential target, are discussed.
Keywords: Insulin degrading enzyme, Alzheimer’s disease, Type 2 Diabetes mellitus, Caenorhabditis elegans.
CNS & Neurological Disorders - Drug Targets
Title:Insulin-Degrading Enzyme: A Link Between Alzheimer’s and Type 2 Diabetes Mellitus
Volume: 13 Issue: 2
Author(s): Rizwanul Haque and Aamir Nazir
Affiliation:
Keywords: Insulin degrading enzyme, Alzheimer’s disease, Type 2 Diabetes mellitus, Caenorhabditis elegans.
Abstract: Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer’s disease. Recent studies provide inkling for the use of IDE as a potential target hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes mellitus and Alzheimer’s disease and the approaches that make IDE a potential target, are discussed.
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Cite this article as:
Haque Rizwanul and Nazir Aamir, Insulin-Degrading Enzyme: A Link Between Alzheimer’s and Type 2 Diabetes Mellitus, CNS & Neurological Disorders - Drug Targets 2014; 13 (2) . https://dx.doi.org/10.2174/18715273113126660139
DOI https://dx.doi.org/10.2174/18715273113126660139 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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