Abstract
Recovery from traumatic brain injury (TBI) is variable despite similarities in the severity or mechanism of injury. The study of genetic polymorphisms offers an avenue for explaining individual differences in recovery and outcome following TBI. The current paper reviews the role that genetic polymorphisms may play in influencing recovery and quality of life following TBI. Investigating the role of polymorphisms on recovery from TBI may contribute to a better understanding of individual variations in outcome and has the potential to lead to earlier and more targeted interventions and rehabilitation based on a patient’s genetic makeup. By outlining what has been discovered about the relationship between polymorphisms and TBI we hope to both inform the medical community about the potential for polymorphisms to influence recovery following TBI and provide a roadmap to researchers about the gaps in research within this population.
Keywords: Traumatic Brain Injury, Polymorphisms, Genes.
Current Pharmaceutical Design
Title:Neurobiological Influences on Recovery from Traumatic Brain Injury: The Role of Genetic Polymorphisms
Volume: 20 Issue: 26
Author(s): Starla M. Weaver and Jaclyn N. Portelli
Affiliation:
Keywords: Traumatic Brain Injury, Polymorphisms, Genes.
Abstract: Recovery from traumatic brain injury (TBI) is variable despite similarities in the severity or mechanism of injury. The study of genetic polymorphisms offers an avenue for explaining individual differences in recovery and outcome following TBI. The current paper reviews the role that genetic polymorphisms may play in influencing recovery and quality of life following TBI. Investigating the role of polymorphisms on recovery from TBI may contribute to a better understanding of individual variations in outcome and has the potential to lead to earlier and more targeted interventions and rehabilitation based on a patient’s genetic makeup. By outlining what has been discovered about the relationship between polymorphisms and TBI we hope to both inform the medical community about the potential for polymorphisms to influence recovery following TBI and provide a roadmap to researchers about the gaps in research within this population.
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Cite this article as:
Weaver M. Starla and Portelli N. Jaclyn, Neurobiological Influences on Recovery from Traumatic Brain Injury: The Role of Genetic Polymorphisms, Current Pharmaceutical Design 2014; 20 (26) . https://dx.doi.org/10.2174/13816128113196660657
DOI https://dx.doi.org/10.2174/13816128113196660657 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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