Efficient Copper-catalyzed Cyanation of Aryl Bromides Using 1,3-phenylene- bis-(1H)-tetrazole as an Efficient Ligand

Title:Efficient Copper-catalyzed Cyanation of Aryl Bromides Using 1,3-phenylene- bis-(1H)-tetrazole as an Efficient Ligand

Volume: 11 Issue: 7

Author(s): Siavash Bahari and Akbar Rezaei

Affiliation:

Keywords: Aryl nitrile, 1, 3-Phenylene-bis-(1H)-tetrazole, Aryl bromide, Cyanation, K₄Fe(CN)₆, Copper acetate.

Abstract: A new method for the synthesis of aryl nitriles has been developed by the cyanation of aryl bromides with K₄Fe(CN)₆ as a cyanide source in the presence of Cu(OAc)₂.H₂O as an inexpensive catalyst and a 1,3-phenylene-bis- (1H)-tetrazole ligand. This method has the advantages of high yield, simple methodology and easy work-up.

Cite this article as:

Bahari Siavash and Rezaei Akbar, Efficient Copper-catalyzed Cyanation of Aryl Bromides Using 1,3-phenylene- bis-(1H)-tetrazole as an Efficient Ligand, Letters in Organic Chemistry 2014; 11 (7) . https://dx.doi.org/10.2174/15701786113109990055