Abstract
We report recent postmortem findings from the Magdeburg Brain Bank related to the evaluation of impaired activity of neuronal networks relevant for depression. Chronic changes in ribosomal DNA transcriptional activity have been revealed by the quantitative evaluation of silver-stained nucleolar organising regions (AgNORs). Abnormalities in AgNOR parameters have been found in neurons of the prefrontal limbic regions, the amygdala, the external globus pallidus, and the serotonergic dorsal raphe nucleus (DRN). The impact of the processes leading to suicide has been clearly accentuated in opposition to the weak influence of unipolar-bipolar dichotomy, which was only revealed in one area (the anterior cingulate cortex). The impact of suicide was most pronounced in the DRN. Our AgNOR studies show that the influence of psychotropic medication (antidepressants and typical neuroleptics, among others) is limited in the prevention of abnormal neuronal activity specific for suicide.
Keywords: Depression, suicide, unipolar-bipolar dichotomy, postmortem, AgNOR staining.
CNS & Neurological Disorders - Drug Targets
Title:Postmortem-Assessed Impairment of Neuronal Activity in Depression: The Dominant Impact of Suicide
Volume: 12 Issue: 7
Author(s): Tomasz Gos, Johann Steiner, Zbigniew Jankowski and Bernhard Bogerts
Affiliation:
Keywords: Depression, suicide, unipolar-bipolar dichotomy, postmortem, AgNOR staining.
Abstract: We report recent postmortem findings from the Magdeburg Brain Bank related to the evaluation of impaired activity of neuronal networks relevant for depression. Chronic changes in ribosomal DNA transcriptional activity have been revealed by the quantitative evaluation of silver-stained nucleolar organising regions (AgNORs). Abnormalities in AgNOR parameters have been found in neurons of the prefrontal limbic regions, the amygdala, the external globus pallidus, and the serotonergic dorsal raphe nucleus (DRN). The impact of the processes leading to suicide has been clearly accentuated in opposition to the weak influence of unipolar-bipolar dichotomy, which was only revealed in one area (the anterior cingulate cortex). The impact of suicide was most pronounced in the DRN. Our AgNOR studies show that the influence of psychotropic medication (antidepressants and typical neuroleptics, among others) is limited in the prevention of abnormal neuronal activity specific for suicide.
Export Options
About this article
Cite this article as:
Gos Tomasz, Steiner Johann, Jankowski Zbigniew and Bogerts Bernhard, Postmortem-Assessed Impairment of Neuronal Activity in Depression: The Dominant Impact of Suicide, CNS & Neurological Disorders - Drug Targets 2013; 12 (7) . https://dx.doi.org/10.2174/18715273113129990094
DOI https://dx.doi.org/10.2174/18715273113129990094 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Advances in Biomarker Research for Pancreatic Cancer
Current Pharmaceutical Design Herpes Simplex Virus Type 1 Amplicons and their Hybrid Virus Partners, EBV, AAV, and Retrovirus
Current Gene Therapy Monoclonal Antibodies in the Treatment of Neuroimmunological Diseases
Current Pharmaceutical Design Immunotherapy with Tumor Vaccines for the Treatment of Malignant Gliomas
Current Drug Discovery Technologies Microbial Metabolomics
Current Genomics Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders
Mini-Reviews in Medicinal Chemistry Naturally Occurring Chitosan and Chitosan Derivatives: A Review
Current Drug Therapy Regulation of Leptin Receptor Expression in Human Polarized Caco-2/15 Cells
Endocrine, Metabolic & Immune Disorders - Drug Targets Contextualizing the Genes Altered in Bladder Neoplasms in Pediatric and Teen Patients Allows Identifying Two Main Classes of Biological Processes Involved and New Potential Therapeutic Targets
Current Genomics The Origin of Lentivirus Research: Maedi-Visna Virus
Current HIV Research Metal Oxide Nanomaterials in Nanomedicine: Applications in Photodynamic Therapy and Potential Toxicity
Current Topics in Medicinal Chemistry Pharmacological Properties and Therapeutic Potential of Naringenin: A Citrus Flavonoid of Pharmaceutical Promise
Current Pharmaceutical Design Clinical Application of Ghrelin
Current Pharmaceutical Design Editorial [Hot Topic: Coming Back to Nature: Plants as a Vital Source of Pharmaceutically Important Metabolites (Guest Editor: Milen I. Georgiev)]
Current Medicinal Chemistry Fibroblast Activation Protein in Remodeling Tissues
Current Molecular Medicine Synthesis and Evaluation of Compounds Containing 4-arylpiperazinyl Moieties Linked to a 2-(pyridin-3-yl)-1H-benzimidazole as p38 MAP Kinase Inhibitors
Letters in Drug Design & Discovery The Renin-angiotensin System as a Target of Novel Anticancer Therapy
Current Pharmaceutical Design Sigma-2 Receptor as a Potential Drug Target
Current Medicinal Chemistry The Chemistry and Pharmacology of Genistein
The Natural Products Journal Iron Deficiency: The Hidden Miscreant in Inflammatory Bowel Disease
Current Drug Targets