Abstract
ASIA syndrome, “Autoimmune (Auto-inflammatory) Syndromes Induced by Adjuvants” includes at least four conditions which share a similar complex of signs and symptoms and have been defined by hyperactive immune responses: siliconosis, macrophagic myofasciitis syndrome, Gulf war syndrome and post-vaccination phenomena. Exposure to adjuvants has been documented in these four medical conditions, suggesting that the common denominator to these syndromes is a trigger entailing adjuvant activity. An important role of animal models in proving the ASIA concept has been established. Experimentally animal models of autoimmune diseases induced by adjuvants are currently widely used to understand the mechanisms and etiology and pathogenesis of these diseases and might thus promote the development of new diagnostic, predictive and therapeutic methods. In the current review we wish to unveil the variety of ASIA animal models associated with systemic and organ specific autoimmune diseases induced by adjuvants. We included in this review animal models for rheumatoid arthritis-like disease, for systemic lupus erythematosus-like disease, autoimmune thyroid disease-like disease, antiphospholipid syndrome, myocarditis and others. All these models support the concept of ASIA, as the Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants.
Keywords: Autoimmune syndrome, adjuvants, ASIA, animal models, auto-inflammatory syndrome.
Current Medicinal Chemistry
Title:Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants (ASIA) – Animal Models as a Proof of Concept
Volume: 20 Issue: 32
Author(s): Paola Cruz-Tapias, Nancy Agmon-Levin, Eitan Israeli, Juan-Manuel Anaya and Yehuda Shoenfeld
Affiliation:
Keywords: Autoimmune syndrome, adjuvants, ASIA, animal models, auto-inflammatory syndrome.
Abstract: ASIA syndrome, “Autoimmune (Auto-inflammatory) Syndromes Induced by Adjuvants” includes at least four conditions which share a similar complex of signs and symptoms and have been defined by hyperactive immune responses: siliconosis, macrophagic myofasciitis syndrome, Gulf war syndrome and post-vaccination phenomena. Exposure to adjuvants has been documented in these four medical conditions, suggesting that the common denominator to these syndromes is a trigger entailing adjuvant activity. An important role of animal models in proving the ASIA concept has been established. Experimentally animal models of autoimmune diseases induced by adjuvants are currently widely used to understand the mechanisms and etiology and pathogenesis of these diseases and might thus promote the development of new diagnostic, predictive and therapeutic methods. In the current review we wish to unveil the variety of ASIA animal models associated with systemic and organ specific autoimmune diseases induced by adjuvants. We included in this review animal models for rheumatoid arthritis-like disease, for systemic lupus erythematosus-like disease, autoimmune thyroid disease-like disease, antiphospholipid syndrome, myocarditis and others. All these models support the concept of ASIA, as the Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants.
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Cite this article as:
Cruz-Tapias Paola, Agmon-Levin Nancy, Israeli Eitan, Anaya Juan-Manuel and Shoenfeld Yehuda, Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants (ASIA) – Animal Models as a Proof of Concept, Current Medicinal Chemistry 2013; 20 (32) . https://dx.doi.org/10.2174/09298673113209990253
DOI https://dx.doi.org/10.2174/09298673113209990253 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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