Abstract
Traditional medicine is very popular in Africa and it is considered as an alternative form of health care. Plants and vegetables used in folk and traditional medicine have gained wide acceptance as one of the main sources of prophylactic and chemopreventive drug discovery and this is due to the evidence of particular biological and biochemical characteristics of each plants extracts. The role of these compounds in urological field may be explained by the antiinflammatory effect through interference with prostaglandin metabolism, alteration of lipid peroxidation, direct inhibition of prostate growth and moreover through an antiandrogenic or antiestrogenic effect and a decrease of the availability of sex hormone-binding globulin. Since Benign Prostatic Hyperplasia and Prostate Cancer are two of the most diffuse diseases of aging male and considering that standard medical therapy is accompanied with different side effects, the emerging use of African plants may be justified. This review takes a look at some African plants extracts properties and their relative urological application. Different biomolecular mechanisms of action are promising, suggesting a real application in reducing prostate cells proliferation.
Keywords: Benign prostatic hyperplasia, prostate cancer, pygeum africanum, hypoxis hemerocallidea, hypericum perforatum, nerium oleander, African plants.
Mini-Reviews in Medicinal Chemistry
Title:Potential Efficacy of Some African Plants in Benign Prostatic Hyperplasia and Prostate Cancer
Volume: 13 Issue: 11
Author(s): Giorgio I. Russo, Sebastiano Cimino, Costanza Salamone, Massimo Madonia, Vincenzo Favilla, Tommaso Castelli and Giuseppe Morgia
Affiliation:
Keywords: Benign prostatic hyperplasia, prostate cancer, pygeum africanum, hypoxis hemerocallidea, hypericum perforatum, nerium oleander, African plants.
Abstract: Traditional medicine is very popular in Africa and it is considered as an alternative form of health care. Plants and vegetables used in folk and traditional medicine have gained wide acceptance as one of the main sources of prophylactic and chemopreventive drug discovery and this is due to the evidence of particular biological and biochemical characteristics of each plants extracts. The role of these compounds in urological field may be explained by the antiinflammatory effect through interference with prostaglandin metabolism, alteration of lipid peroxidation, direct inhibition of prostate growth and moreover through an antiandrogenic or antiestrogenic effect and a decrease of the availability of sex hormone-binding globulin. Since Benign Prostatic Hyperplasia and Prostate Cancer are two of the most diffuse diseases of aging male and considering that standard medical therapy is accompanied with different side effects, the emerging use of African plants may be justified. This review takes a look at some African plants extracts properties and their relative urological application. Different biomolecular mechanisms of action are promising, suggesting a real application in reducing prostate cells proliferation.
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Russo I. Giorgio, Cimino Sebastiano, Salamone Costanza, Madonia Massimo, Favilla Vincenzo, Castelli Tommaso and Morgia Giuseppe, Potential Efficacy of Some African Plants in Benign Prostatic Hyperplasia and Prostate Cancer, Mini-Reviews in Medicinal Chemistry 2013; 13 (11) . https://dx.doi.org/10.2174/13895575113139990008
DOI https://dx.doi.org/10.2174/13895575113139990008 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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