Abstract
Objectives. To review the role of Wnt pathways in the neurodevelopment of schizophrenia.
Methods: Systematic PubMed search, using as keywords all the terms related to the Wnt pathways and crossing them with each of the following areas: normal neurodevelopment and physiology, neurodevelopmental theory of schizophrenia, schizophrenia, and antipsychotic drug action.
Results: Neurodevelopmental, behavioural, genetic, and psychopharmacological data point to the possible involvement of Wnt systems, especially the canonical pathway, in the pathophysiology of schizophrenia and in the mechanism of antipsychotic drug action. The molecules most consistently found to be associated with abnormalities or in antipsychotic drug action are Akt1, glycogen synthase kinase3beta, and beta-catenin. However, the extent to which they contribute to the pathophysiology of schizophrenia or to antipsychotic action remains to be established.
Conclusions: The study of the involvement of Wnt pathway abnormalities in schizophrenia may help in understanding this multifaceted clinical entity; the development of Wnt-related pharmacological targets must await the collection of more data.
Keywords: Antipsychotic Drugs; Neurodevelopment; Schizophrenia; Wingless (Wnt) signalling.
Current Neuropharmacology
Title:Neurodevelopment in Schizophrenia: The Role of the Wnt Pathways
Volume: 11 Issue: 5
Author(s): Elisa Ambrosi, Gabriele Sani, Paolo Girardi, Ferdinando Nicoletti, Marta Motolese, Delfina Janiri, Giovanni Manfredi, Emanuela Danese, Lavinia De Chiara, Valeria Savoja, Alessio Simonetti, Isabella Panaccione, Ilaria Cuomo, Federica Caccia, Daniele Serata, Chiara Brugnoli, Chiara Rapinesi, Antonio Del Casale, Giorgio D. Kotzalidis, Alberto Maria Forte and Flavia Napoletano
Affiliation:
Keywords: Antipsychotic Drugs; Neurodevelopment; Schizophrenia; Wingless (Wnt) signalling.
Abstract: Objectives. To review the role of Wnt pathways in the neurodevelopment of schizophrenia.
Methods: Systematic PubMed search, using as keywords all the terms related to the Wnt pathways and crossing them with each of the following areas: normal neurodevelopment and physiology, neurodevelopmental theory of schizophrenia, schizophrenia, and antipsychotic drug action.
Results: Neurodevelopmental, behavioural, genetic, and psychopharmacological data point to the possible involvement of Wnt systems, especially the canonical pathway, in the pathophysiology of schizophrenia and in the mechanism of antipsychotic drug action. The molecules most consistently found to be associated with abnormalities or in antipsychotic drug action are Akt1, glycogen synthase kinase3beta, and beta-catenin. However, the extent to which they contribute to the pathophysiology of schizophrenia or to antipsychotic action remains to be established.
Conclusions: The study of the involvement of Wnt pathway abnormalities in schizophrenia may help in understanding this multifaceted clinical entity; the development of Wnt-related pharmacological targets must await the collection of more data.
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Ambrosi Elisa, Sani Gabriele, Girardi Paolo, Nicoletti Ferdinando, Motolese Marta, Janiri Delfina, Manfredi Giovanni, Danese Emanuela, Chiara De Lavinia, Savoja Valeria, Simonetti Alessio, Panaccione Isabella, Cuomo Ilaria, Caccia Federica, Serata Daniele, Brugnoli Chiara, Rapinesi Chiara, Casale Del Antonio, Kotzalidis D. Giorgio, Forte Maria Alberto and Napoletano Flavia, Neurodevelopment in Schizophrenia: The Role of the Wnt Pathways, Current Neuropharmacology 2013; 11 (5) . https://dx.doi.org/10.2174/1570159X113119990037
DOI https://dx.doi.org/10.2174/1570159X113119990037 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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