Abstract
Several 4H-pyrano[3,2-h]quinolone (3, 5, 7, 8, 10, 11, 14, 15, 16 and 17) and 7H-pyrimido[4',5':- 6,5]pyrano[3,2-h]quinoline derivatives (9, 12, 13, 18) were prepared. These compounds were tested in vitro for their antimicrobial activity to show congruent results against the most tested microorganisms as compared with the standards Ampicillin, Streptomycin, Mycostatine and Clotrimazole. The structure activity relationship (SAR) studies of 3 and its analog compounds revealed higher potent antimicrobial activity against the most tested microorganisms. These data indicated that the activity of compounds was considerably attributed to the presence of the electrondonating groups in combination with the electron-withdrawing groups in 4H-pyrano[3,2-h]quinoline moiety. Incorporating a pyrimidine nucleus with pyranoquinoline moiety resulted in changing the potency for some compound. The structures of these compounds were established on the basis of spectral data.
Keywords: 8-Hydroxyquinoline, 8-Hydroxy-2-methylquinoline, (E) 2-(4-Chloro/bromo/-fluorostyryl)-8-hydroxyquinoline, Antimicrobial, SAR.
Letters in Drug Design & Discovery
Title:Evaluation of the Antimicrobial Activity of Some 4H-Pyrano[3,2-h]- quinoline,7H-Pyrimido[4',5':6,5]pyrano[3,2-h]quinoline Derivatives
Volume: 10 Issue: 8
Author(s): Hany M. Mohamed, Ibrahim A. Radini, Abdullah M. Al-Ghamdi and Ahmed M. El-Agrody
Affiliation:
Keywords: 8-Hydroxyquinoline, 8-Hydroxy-2-methylquinoline, (E) 2-(4-Chloro/bromo/-fluorostyryl)-8-hydroxyquinoline, Antimicrobial, SAR.
Abstract: Several 4H-pyrano[3,2-h]quinolone (3, 5, 7, 8, 10, 11, 14, 15, 16 and 17) and 7H-pyrimido[4',5':- 6,5]pyrano[3,2-h]quinoline derivatives (9, 12, 13, 18) were prepared. These compounds were tested in vitro for their antimicrobial activity to show congruent results against the most tested microorganisms as compared with the standards Ampicillin, Streptomycin, Mycostatine and Clotrimazole. The structure activity relationship (SAR) studies of 3 and its analog compounds revealed higher potent antimicrobial activity against the most tested microorganisms. These data indicated that the activity of compounds was considerably attributed to the presence of the electrondonating groups in combination with the electron-withdrawing groups in 4H-pyrano[3,2-h]quinoline moiety. Incorporating a pyrimidine nucleus with pyranoquinoline moiety resulted in changing the potency for some compound. The structures of these compounds were established on the basis of spectral data.
Export Options
About this article
Cite this article as:
Mohamed M. Hany, Radini A. Ibrahim, Al-Ghamdi M. Abdullah and El-Agrody M. Ahmed, Evaluation of the Antimicrobial Activity of Some 4H-Pyrano[3,2-h]- quinoline,7H-Pyrimido[4',5':6,5]pyrano[3,2-h]quinoline Derivatives, Letters in Drug Design & Discovery 2013; 10 (8) . https://dx.doi.org/10.2174/15701808113109990002
DOI https://dx.doi.org/10.2174/15701808113109990002 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mitochondria Sentencing About Cellular Life and Death: A Matter of Oxidative Stress
Current Pharmaceutical Design Synergistic Effect of Graphene Oxide Coated Nanotised Apigenin with Paclitaxel (GO-NA/PTX): A ROS Dependent Mitochondrial Mediated Apoptosis in Ovarian Cancer
Anti-Cancer Agents in Medicinal Chemistry Expectancy and the Treatment of Depression: A Review of Experimental Methodology and Effects on Patient Outcome
Current Psychiatry Reviews Microemulsions for Colorectal Cancer Treatments. General Considerations and Formulation of Methotrexate
Mini-Reviews in Medicinal Chemistry An Apple Plus a Brazil Nut a Day Keeps the Doctors Away: Antioxidant Capacity of Foods and their Health Benefits
Current Pharmaceutical Design Biological Activities of Yarrow Species (Achillea spp.)
Current Pharmaceutical Design Tool Developments for Structure-Function Studies of Host Defense Peptides
Protein & Peptide Letters Synthesis and Broad Spectrum Antibacterial Activity of Magnetite Ferrofluid
Current Nanoscience Efficacy and Cardiovascular Safety of Metformin
Current Drug Safety Sub Cellular Organelles-targeting Photo Dynamic Therapy (PDT)
Mini-Reviews in Organic Chemistry The Cardiovascular Nutrapharmacology of Resveratrol: Pharmacokinetics, Molecular Mechanisms and Therapeutic Potential
Current Medicinal Chemistry Metabolite Interference in Pharmacokinetic Studies
Drug Metabolism Letters Tailored Quinolines Demonstrate Flexibility to Exert Antitumor Effects through Varied Mechanisms-A Medicinal Perspective
Anti-Cancer Agents in Medicinal Chemistry Acid-Induced Unfolding of Champedak Galactose-Binding Lectin
Protein & Peptide Letters Aptamers as Therapeutics in Cardiovascular Diseases
Current Medicinal Chemistry Recent Advances in Nanosystems and Strategies for Managing Leishmaniasis
Current Drug Targets Laparoscopic Reconstructive Surgery in Pediatric Urology: An Overview of Current Options
Current Pediatric Reviews Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays
Current Pharmaceutical Design Structural Determinants of the Multifunctional Profile of Dual Binding Site Acetylcholinesterase Inhibitors as Anti-Alzheimer Agents
Current Pharmaceutical Design Health Benefits of Manuka Honey as an Essential Constituent for Tissue Regeneration
Current Drug Metabolism