Generic placeholder image

Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

MicroRNAs and Cancer Therapy – From Bystanders to Major Players

Author(s): Cornelia Braicu, George A. Calin and Ioana Berindan-Neagoe

Volume 20, Issue 29, 2013

Page: [3561 - 3573] Pages: 13

DOI: 10.2174/0929867311320290002

Abstract

MicroRNAs (miRNAs) are an evolutionarily conserved class of small regulatory RNAs that modulate gene expression. Extensive research over the last decade has shown that miRNAs are master regulators of cellular processes, with an essential role in cancer initiation, progression, and metastasis. Widespread deregulation of miRNAs in cancers has identified oncogenic and tumor-suppressive roles for these miRNAs. On the basis of these observations, miRNAs have emerged as promising therapeutic tools for cancer management. In this review, we focus on the roles of miRNAs in tumorigenesis, the rationale and strategies for the use of miRNA-based therapy for cancer, and the advantages and current challenges to their use.

Keywords: Cancer, microRNA, miRNA cascade, miRNA- based therapy.


© 2024 Bentham Science Publishers | Privacy Policy