Abstract
The aim of this review is to summarize the current magnetic resonance imaging (MRI) variants applied on the studies of Alzheimer’s disease (AD). Experimental findings, advantages and disadvantages, and the prospect of every individual technique will be presented. MRI can be used to investigate the change of the brain in terms of volume, function, white matter track orientation and even mechanical properties and metabolic concentration.Results from volumetric and morphological analysis indicated that the hippocampus reduced by approximately 18%-24% or 3%-4% annually. Functional MRI (fMRI) detected the blood oxygen level dependent (BOLD) signaland suggested thatmedial temporal lobe (MTL) such as hippocampus and entorhinal cortex reduced at the early stage of AD, and frontal, temporal, and parietal cortices at the later stage. In diffusion tensor imaging (DTI), the white matter fiber track integrity is measured but the results are inconsistent. Besides,magnetic resonance spectroscopy (MRS), chemical shift imaging (CSI), arterial spin labeling (ASL), magnetic resonance elastography (MRE) and susceptibility weighted imaging (SWI) will also be included in this review.
Keywords: Alzheimer’s disease, Multimodal MRI, fMRI, DTI, MRS, amyloid, tau pathology.
Current Alzheimer Research
Title:Application of Multimodal MR Imaging on Studying Alzheimer's Disease: A Survey
Volume: 10 Issue: 8
Author(s): Defeng Wang, Steve CN Hui, Lin Shi, Wen-hua Huang, Tianfu Wang, Vincent CT Mok, Winnie CW Chu and Anil T Ahuja
Affiliation:
Keywords: Alzheimer’s disease, Multimodal MRI, fMRI, DTI, MRS, amyloid, tau pathology.
Abstract: The aim of this review is to summarize the current magnetic resonance imaging (MRI) variants applied on the studies of Alzheimer’s disease (AD). Experimental findings, advantages and disadvantages, and the prospect of every individual technique will be presented. MRI can be used to investigate the change of the brain in terms of volume, function, white matter track orientation and even mechanical properties and metabolic concentration.Results from volumetric and morphological analysis indicated that the hippocampus reduced by approximately 18%-24% or 3%-4% annually. Functional MRI (fMRI) detected the blood oxygen level dependent (BOLD) signaland suggested thatmedial temporal lobe (MTL) such as hippocampus and entorhinal cortex reduced at the early stage of AD, and frontal, temporal, and parietal cortices at the later stage. In diffusion tensor imaging (DTI), the white matter fiber track integrity is measured but the results are inconsistent. Besides,magnetic resonance spectroscopy (MRS), chemical shift imaging (CSI), arterial spin labeling (ASL), magnetic resonance elastography (MRE) and susceptibility weighted imaging (SWI) will also be included in this review.
Export Options
About this article
Cite this article as:
Wang Defeng, Hui CN Steve, Shi Lin, Huang Wen-hua, Wang Tianfu, Mok CT Vincent, Chu CW Winnie and Ahuja T Anil, Application of Multimodal MR Imaging on Studying Alzheimer's Disease: A Survey, Current Alzheimer Research 2013; 10 (8) . https://dx.doi.org/10.2174/15672050113109990150
DOI https://dx.doi.org/10.2174/15672050113109990150 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Use of Anti-Epileptic Medication in Women with Affective Disorders in Early and Late Pregnancy and During Breastfeeding
Current Women`s Health Reviews A Current Review of Cypermethrin-Induced Neurotoxicity and Nigrostriatal Dopaminergic Neurodegeneration
Current Neuropharmacology Endocannabinoids in Liver Disease and Hepatic Encephalopathy
Current Pharmaceutical Design The Impact of Computer Science in Molecular Medicine: Enabling High- Throughput Research
Current Topics in Medicinal Chemistry Editorial [Hot Topic: Analgesic Drug Discovery: Promising Future (Guest Editor: Anindya Bhattacharya)]
Current Pharmaceutical Biotechnology Pregnancy, Physical Activity, Functional Capacity and Adaptations to Exercise
Current Women`s Health Reviews Biology and Clinical Management of Myeloproliferative Neoplasms and Development of the JAK Inhibitor Ruxolitinib
Current Medicinal Chemistry Ginsenoside RB1 Reduces Neurologic Damage, is Anti-Apoptotic, and Down-Regulates p53 and BAX in Subarachnoid Hemorrhage
Current Neurovascular Research Structural Analysis of Relevant Drug Targets for Alzheimer's Disease: Novel Approaches to Drug Development
Current Bioactive Compounds The IL23/Th17 Pathway as a Therapeutic Target in Chronic Inflammatory Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Insulin-Degrading Enzyme: A Link Between Alzheimer’s and Type 2 Diabetes Mellitus
CNS & Neurological Disorders - Drug Targets Intramolecular Processes and Their Applications in Prodrugs Approaches- Experimental and Computational Studies
Current Organic Chemistry Controlling Apoptosis by Inhibition of Caspases
Current Medicinal Chemistry GABAergic Functions and Depression: From Classical Therapies to Herbal Medicine
Current Drug Targets - CNS & Neurological Disorders Autophagy : Moving Benchside Promises to Patient Bedsides
Current Cancer Drug Targets Evaluation of in vivo Anti-inflammatory and Analgesic Activities of Novel Derivatives of Ugi-4CR
Mini-Reviews in Medicinal Chemistry Reducing Perioperative Myocardial Infarction with Anesthetic Drugs and Techniques
Current Drug Targets Editorial (Thematic Issue: Disorders of Consciousness: Recent Advances in Neurobiology and Treatments)
Current Pharmaceutical Design Naturalistic Measurement of Sleep in Older Adults with Amnestic Mild Cognitive Impairment: Anxiety Symptoms Do Not Explain Sleep Disturbance
Current Alzheimer Research Applications of Animal Models of Infectious Arthritis in Drug Discovery:A focus on Alphaviral Disease
Current Drug Targets