Abstract
Although Camptothecin (CPT) has significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers; lactone ring opening causes a reduction in cytotoxic activity and severe side effects in physiological conditions (pH: 7.4, 37°C) due to decreased cell membrane binding, membrane diffusibility, and intrinsic potency against the topoisomerase target. Taken into consideration the targeted delivery advantage of biocompatible magnetic particles, in order to contribute to the removal of the handicap (lactone ring opening), the current study investigated stability, release, and in vitro bioactivity of CPT in oleic acid (OA)-pluronic F127 (PL) coated iron oxide micro and nanoparticles. CPT encapsulated magnetite micro (~10 μm) and nano (~30 nm) formulations were synthesized without changing their magnetic properties. Analysis of encapsulated CPT illustrated that over 99% of the lactone form was protected in the magnetic particle formulations and release of CPT from the magnetic micro and nanoparticles lasted for 9 and 4 days respectively. In addition, in a representative in vitro cytotoxicity study, CPT encapsulated OA-PL stabilized magnetite microparticles were approximately 65% more effective than free CPT to inhibit 100% cell growth on three different human liver carcinoma cell lines. Therefore, the OA-PL stabilized iron oxide formulation is ideal for achieving targeted and sustained CPT delivery in bioactive lactone form to overcome its handicaps in clinical conditions.
Keywords: Cancer chemotherapy, cell culture, targeted drug delivery, microparticles, nanoparticles, camptothecin, iron oxide.
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Books
Nanoscale Field Effect Transistors: Emerging Applications
Nanoelectronics Devices: Design, Materials, and Applications Part II
Nanoelectronics Devices: Design, Materials, and Applications (Part I)
Role of Nanotechnology in Cancer Therapy
Synthesis and Applications of Semiconductor Nanostructures
Pathways to Green Nanomaterials: Plants as Raw Materials, Reducing Agents and Hosts
Applications of Nanomaterials in Medical Procedures and Treatments
Synthesis of Nanomaterials
Nanobiotechnology: Principles and Applications
Bio-Inspired Nanotechnology
17