Abstract
A technical improvement enabling efficient and reproducible stem cell cultures is one of the most important aspects in stem cell research and cell-based therapy. For this purpose, researchers have used various cytokine cocktails and gene transfection techniques to proliferate stem cells. However, stem cell fate can reportedly be determined by physical stimuli such as gravity, electrical fields, and magnetic fields. In this regard, we have developed a novel technique utilizing a clinostat, a device capable of generating a controlled microgravity environment for robust maintenance of stem cell state. Here, we review our recent progress in expansion and differentiation of stem cells grown under simulated microgravity environment and their utility for transplantation in animal models of cartilage deficiency and neurotrauma.
Keywords: Simulated microgravity, stem cell, cell differentiation, cell-based therapy.
Current Biotechnology
Title:Simulated Microgravity Based Stem Cell Cultures Enhance Their Utility for Cell-Based Therapy
Volume: 2 Issue: 3
Author(s): Yumi Kawahara and Louis Yuge
Affiliation:
Keywords: Simulated microgravity, stem cell, cell differentiation, cell-based therapy.
Abstract: A technical improvement enabling efficient and reproducible stem cell cultures is one of the most important aspects in stem cell research and cell-based therapy. For this purpose, researchers have used various cytokine cocktails and gene transfection techniques to proliferate stem cells. However, stem cell fate can reportedly be determined by physical stimuli such as gravity, electrical fields, and magnetic fields. In this regard, we have developed a novel technique utilizing a clinostat, a device capable of generating a controlled microgravity environment for robust maintenance of stem cell state. Here, we review our recent progress in expansion and differentiation of stem cells grown under simulated microgravity environment and their utility for transplantation in animal models of cartilage deficiency and neurotrauma.
Export Options
About this article
Cite this article as:
Kawahara Yumi and Yuge Louis, Simulated Microgravity Based Stem Cell Cultures Enhance Their Utility for Cell-Based Therapy, Current Biotechnology 2013; 2 (3) . https://dx.doi.org/10.2174/22115501113029990020
DOI https://dx.doi.org/10.2174/22115501113029990020 |
Print ISSN 2211-5501 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-551X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Role of Proprioception in Osteoarthritis of the Hand and Wrist
Current Rheumatology Reviews Evaluation of the Radioprotective Effects of Melatonin Against Ionizing Radiation-Induced Muscle Tissue Injury
Current Radiopharmaceuticals Neurotrophin Receptor Signaling as a Therapeutic Target for Huntington's Disease
CNS & Neurological Disorders - Drug Targets Epigenetic Drugs for Multiple Sclerosis
Current Neuropharmacology Cellular and Biochemical Actions of Melatonin which Protect Against Free Radicals: Role in Neurodegenerative Disorders
Current Neuropharmacology HSV-1-Derived Recombinant and Amplicon Vectors for Gene Transfer and Gene Therapy
Current Gene Therapy Astrocytic Signaling in Persistent Pain
Current Signal Transduction Therapy Vanilloid Receptor Antagonists: Emerging Class of Novel Anti-Inflammatory Agents for Pain Management
Current Pharmaceutical Design The Effects of Creatine Supplementation and Physical Exercise on Traumatic Brain Injury
Mini-Reviews in Medicinal Chemistry Roles of Arterial Baroreceptor Reflex During Bezold-Jarisch Reflex
Current Cardiology Reviews Anticancer Mechanisms of Berberine: A Good Choice for Glioblastoma Multiforme Therapy
Current Medicinal Chemistry Pathophysiology and Treatment of Diabetic Peripheral Neuropathy: The Case for Diabetic Neurovascular Function as an Essential Component
Current Diabetes Reviews Osteogenic Differentiation of Orofacial Tissue-Derived Mesenchymal Stem Cells- A Review
Current Tissue Engineering (Discontinued) Necessity for Re-Vascularization after Spinal Cord Injury and the Search for Potential Therapeutic Options
Current Neurovascular Research Cannabinoids
Current Drug Targets - CNS & Neurological Disorders Multiple Hormonal Dysregulation as Determinant of Low Physical Performance and Mobility in Older Persons
Current Pharmaceutical Design Nuclear Imaging of Inflammation in Neurologic and Psychiatric Disorders
Current Clinical Pharmacology Adeno-Associated Virus (AAV) Vectors in the CNS
Current Gene Therapy Endocannabinoids and their Involvement in the Neurovascular System
Current Neurovascular Research Neurobehavioral Evaluation in the Preterm and Term Infant
Current Pediatric Reviews