Abstract
A technical improvement enabling efficient and reproducible stem cell cultures is one of the most important aspects in stem cell research and cell-based therapy. For this purpose, researchers have used various cytokine cocktails and gene transfection techniques to proliferate stem cells. However, stem cell fate can reportedly be determined by physical stimuli such as gravity, electrical fields, and magnetic fields. In this regard, we have developed a novel technique utilizing a clinostat, a device capable of generating a controlled microgravity environment for robust maintenance of stem cell state. Here, we review our recent progress in expansion and differentiation of stem cells grown under simulated microgravity environment and their utility for transplantation in animal models of cartilage deficiency and neurotrauma.
Keywords: Simulated microgravity, stem cell, cell differentiation, cell-based therapy.
Current Biotechnology
Title:Simulated Microgravity Based Stem Cell Cultures Enhance Their Utility for Cell-Based Therapy
Volume: 2 Issue: 3
Author(s): Yumi Kawahara and Louis Yuge
Affiliation:
Keywords: Simulated microgravity, stem cell, cell differentiation, cell-based therapy.
Abstract: A technical improvement enabling efficient and reproducible stem cell cultures is one of the most important aspects in stem cell research and cell-based therapy. For this purpose, researchers have used various cytokine cocktails and gene transfection techniques to proliferate stem cells. However, stem cell fate can reportedly be determined by physical stimuli such as gravity, electrical fields, and magnetic fields. In this regard, we have developed a novel technique utilizing a clinostat, a device capable of generating a controlled microgravity environment for robust maintenance of stem cell state. Here, we review our recent progress in expansion and differentiation of stem cells grown under simulated microgravity environment and their utility for transplantation in animal models of cartilage deficiency and neurotrauma.
Export Options
About this article
Cite this article as:
Kawahara Yumi and Yuge Louis, Simulated Microgravity Based Stem Cell Cultures Enhance Their Utility for Cell-Based Therapy, Current Biotechnology 2013; 2 (3) . https://dx.doi.org/10.2174/22115501113029990020
DOI https://dx.doi.org/10.2174/22115501113029990020 |
Print ISSN 2211-5501 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-551X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Plasma and Tissue Kininogen-kallikrein-kinin System: Role in the Cardiovascular System
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach
Current Neuropharmacology Cortical and Subcortical Changes in Alzheimer’s Disease: A Longitudinal and Quantitative MRI Study
Current Alzheimer Research Peripheral Opioid Analgesia
Current Pharmaceutical Biotechnology Double-Blind, Placebo-Controlled, Randomized Phase I/IIa Study (Safety and Efficacy) with Buspirone/Levodopa/Carbidopa (SpinalonTM) in Subjects with Complete AIS A or Motor-Complete AIS B Spinal Cord Injury
Current Pharmaceutical Design Renin-Angiotensin System in Central Nervous System Diseases and its Interaction with COVID-19
Current Medicinal Chemistry Adult Neural Stem Cells: Response to Stroke Injury and Potential for Therapeutic Applications
Current Stem Cell Research & Therapy The Endocrine Regulation of Stem Cells: Physiological Importance and Pharmacological Potentials for Cell-Based Therapy
Current Stem Cell Research & Therapy Contrasting Roles of the Galectin-3 in the Schizophrenia Onset, Clinical Presentation, and Somatic Comorbidity
Current Topics in Medicinal Chemistry Cross-Talk Between Mesenchymal Stem/Stromal Cells and Dendritic Cells
Current Stem Cell Research & Therapy The Regulation of Neuroimmune-Endocrine Interactions: Mechanisms,Molecular Pathways Unraveled and the Pivotal Role of Cytokines – A Unsung Putative Bidirectional Interdependence between the Immune and Neuroendocrine Interfaces
Current Immunology Reviews (Discontinued) Polyphenols Beyond Barriers: A Glimpse into the Brain
Current Neuropharmacology Immunophilins: Structures, Mechanisms and Ligands
Current Molecular Pharmacology Quantitative Gait Disturbances in Older Adults with Cognitive Impairments
Current Pharmaceutical Design Dual Acting Anti-Inflammatory Drugs
Current Topics in Medicinal Chemistry Recent Updates in Imperative Natural Compounds for Healthy Brain and Nerve Function: A Systematic Review of Implications for Multiple Sclerosis
Current Drug Targets Topical Analgesics in Neuropathic Pain
Current Pharmaceutical Design Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins
Current Molecular Medicine Pharmacological Modulation of Caspase Activation
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Histone Methylation and Transcriptional Regulation in Cardiovascular Disease
Cardiovascular & Hematological Disorders-Drug Targets