An Efficient and Environmentally Benign Four-component Domino Protocol for Synthesis of Spirooxindoles Spiroannulated with Fused Heterosystems of Privileged Heterocycles

Title:An Efficient and Environmentally Benign Four-component Domino Protocol for Synthesis of Spirooxindoles Spiroannulated with Fused Heterosystems of Privileged Heterocycles

Volume: 9 Issue: 3

Author(s): Sarita Khandelwal, Anshu Rajawat and Mahendra Kumar

Affiliation:

Keywords: Chromenopyrazolophthalazines, indazolophthalazines, multicomponent reactions, pyranopyrazolophthalazines, spiroheterocycles, spirooxindoles.

Abstract: An efficient and environmentally benign one- pot four-component domino protocol has been presented for the synthesis of structurally diverse spirooxindoles spiroannulated with chromenopyrazolophthalazines, indazolophthalazines and pyranopyrazolophthalazines involving the reaction of phthalic anhydride, hydrazine hydrate, isatins and cyclic ketones in aqueous alcoholic medium (H₂O-C₂H₅OH: v 5:1) using catalytic amount of sulphamic acid.

Cite this article as:

Khandelwal Sarita, Rajawat Anshu and Kumar Mahendra, An Efficient and Environmentally Benign Four-component Domino Protocol for Synthesis of Spirooxindoles Spiroannulated with Fused Heterosystems of Privileged Heterocycles, Current Bioactive Compounds 2013; 9 (3) . https://dx.doi.org/10.2174/15734072113099990014