Abstract
Amino acid transporters of the SLC6 family mediate the Na+-dependent uptake of neutral amino acids into neurons and epithelial cells of the intestine, kidney and other organs. They are integral parts of amino acid homeostasis in the whole body and the brain. In the intestine they are involved in protein absorption, while in the kidney they regulate plasma amino acid concentrations through reabsorption. The metabolic role of SLC6 amino acid transporters in the brain is less clear and most likely related to anaplerosis of the TCA cycle. Mutations in these transporters cause rare inherited disorders such as Hartnup disorder and iminoglycinuria. They may also play a role in complex traits such as depression, anxiety, obesity, diabetes and cancer. The review does not cover the transport of neurotransmitter amino acids.
Keywords: Cancer, diabetes, hartnup disorder, iminoglycinuria, obesity.
Current Molecular Pharmacology
Title:Diseases Associated with General Amino Acid Transporters of the Solute Carrier 6 Family (SLC6)
Volume: 6
Author(s): Stefan Broer
Affiliation:
Keywords: Cancer, diabetes, hartnup disorder, iminoglycinuria, obesity.
Abstract: Amino acid transporters of the SLC6 family mediate the Na+-dependent uptake of neutral amino acids into neurons and epithelial cells of the intestine, kidney and other organs. They are integral parts of amino acid homeostasis in the whole body and the brain. In the intestine they are involved in protein absorption, while in the kidney they regulate plasma amino acid concentrations through reabsorption. The metabolic role of SLC6 amino acid transporters in the brain is less clear and most likely related to anaplerosis of the TCA cycle. Mutations in these transporters cause rare inherited disorders such as Hartnup disorder and iminoglycinuria. They may also play a role in complex traits such as depression, anxiety, obesity, diabetes and cancer. The review does not cover the transport of neurotransmitter amino acids.
Export Options
About this article
Cite this article as:
Broer Stefan, Diseases Associated with General Amino Acid Transporters of the Solute Carrier 6 Family (SLC6), Current Molecular Pharmacology 2013; 6 (2) . https://dx.doi.org/10.2174/18744672113069990034
DOI https://dx.doi.org/10.2174/18744672113069990034 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Differences in Saccadic Eye Movements in Subjects at High and Low Risk for Panic Disorder
Current Pharmaceutical Design Promising Targets for Anti-Hepatitis C Virus Agents
Current Medicinal Chemistry Seizure Thresholds in Elderly Patients Treated with Electroconvulsive Therapy for Major Depressive Disorder: A Review
Current Psychiatry Reviews Effect of a M1 Allosteric Modulator on Scopolamine-Induced Amnesia
Medicinal Chemistry Blood Brain Barrier Compromise with Endothelial Inflammation may Lead to Autoimmune Loss of Myelin during Multiple Sclerosis
Current Neurovascular Research Functional Interactions Between B Lymphocytes and the Innate Immune System
Infectious Disorders - Drug Targets Concurrent Estimation of Gabapentin and Nortriptyline Hydrochloride in their Combined Dosage Form Using OPA-β-Mercaptoethanol Derivatization by Spectrophotometric and Spectrofluorimetric Methods
Current Pharmaceutical Analysis Cosignaling Complexity Gets More Convoluted: The Emerging Importance of the B7-Like Butyrophilin Family of Immune Regulators
Current Immunology Reviews (Discontinued) Outer Surface Proteins of Borrelia: Peerless Immune Evasion Tools
Current Protein & Peptide Science Antidepressants: Current Strategies and Future Opportunities
Current Pharmaceutical Design Plasma-Rich in Growth Factor and its Clinical Application
Current Stem Cell Research & Therapy New Targets for Therapy in Polyglutamine (polyQ) Expansion Diseases
Current Drug Therapy The Bio-Psycho-Social Dimension in Women’s Sexual Desire: ‘Argumentum ad novitatem’
Current Drug Targets Cognitive Impairment Associated with Parkinson’s Disease: Role of Mitochondria
Current Neuropharmacology Mangrove Plants as a Source of Bioactive Compounds: A Review
The Natural Products Journal Statins and Thrombin
Current Drug Targets - Cardiovascular & Hematological Disorders Understanding Stem Cell-Mediated Brain Repair Through Neuroimaging
Current Stem Cell Research & Therapy Cyclin-Dependent Kinase 5 (Cdk5): A Potential Therapeutic Target for the Treatment of Neurodegenerative Diseases and Diabetes Mellitus
Mini-Reviews in Medicinal Chemistry In Vitro Modeling of the Blood-Brain Barrier: Simplicity Versus Complexity
Current Pharmaceutical Design Biomedical Devices for Pathogen Detection Using Microfluidic Chips
Current Proteomics