Abstract
This paper revisits some aspects of carbon-11 radiochemistry from the production of the primary labeling reagents and fast chemical transformations used to convert them into more useful building blocks such as [11C]methyl iodide and [11C]carbon monoxide. The application facet covers traditional methylation, carboxylation and other reactions in the preparation of PET tracers. Technical aspects and strategies in handling labeling syntheses are also included. Distinct attention is then given to methods for the 11C-labelling of carbamide and carbamate functional groups at the carbonyl position, considering the wide choice of protocols and starting materials that have become available for this purpose. Concluding sections provide an overview of contemporary practices for the purification of labeled compounds and preventing their radiolytic decomposition.
Keywords: Carbon-11, Radiochemistry, Positron Emission Tomography, PET, Review.
Current Organic Chemistry
Title:On 11C Chemistry Reviews - Surveying and Filling the Gaps
Volume: 17 Issue: 19
Author(s): Oleksiy Itsenko, Vanessa Goméz-Vallejo, Jordi Llop and Jacek Koziorowski
Affiliation:
Keywords: Carbon-11, Radiochemistry, Positron Emission Tomography, PET, Review.
Abstract: This paper revisits some aspects of carbon-11 radiochemistry from the production of the primary labeling reagents and fast chemical transformations used to convert them into more useful building blocks such as [11C]methyl iodide and [11C]carbon monoxide. The application facet covers traditional methylation, carboxylation and other reactions in the preparation of PET tracers. Technical aspects and strategies in handling labeling syntheses are also included. Distinct attention is then given to methods for the 11C-labelling of carbamide and carbamate functional groups at the carbonyl position, considering the wide choice of protocols and starting materials that have become available for this purpose. Concluding sections provide an overview of contemporary practices for the purification of labeled compounds and preventing their radiolytic decomposition.
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Cite this article as:
Itsenko Oleksiy, Goméz-Vallejo Vanessa, Llop Jordi and Koziorowski Jacek, On 11C Chemistry Reviews - Surveying and Filling the Gaps, Current Organic Chemistry 2013; 17 (19) . https://dx.doi.org/10.2174/13892029113149990101
DOI https://dx.doi.org/10.2174/13892029113149990101 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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