Abstract
Hemostasis is an intrinsic property of the vascular system that prevents blood loss during accidental disruption of the vessel wall. Late mechanisms of hemostasis comprise vessel repair and wound healing. In contrast, the early mechanism of hemostasis comprises the quick formation of a blood cell plug, also known as thrombus, whose function is to seal the region of the vessel near the compromised surface or area. Despite the simplicity of the concept, the molecular mechanisms underlying early hemostasis are highly complex. The local rheological properties of the blood flow, the vascular region and the nature of the injury determine the mechanism of thrombogenesis. Components of the plasma, blood cells such as platelets and vascular endothelial cells are involved in thrombosis. This review focuses on platelet-vascular wall interactions during thrombosis and hemostasis and provides an overview of the main underlying molecular mechanisms.
Keywords: Coagulation cascade, hemostasis, platelets, thrombosis, vascular endothelial cells.
Current Vascular Pharmacology
Title:Molecular Interplay between Platelets and the Vascular Wall in Thrombosis and Hemostasis
Volume: 11 Issue: 4
Author(s): Alejandro Berna-Erro, Pedro C. Redondo, Esther Lopez, Letizia Albarran and Juan A. Rosado
Affiliation:
Keywords: Coagulation cascade, hemostasis, platelets, thrombosis, vascular endothelial cells.
Abstract: Hemostasis is an intrinsic property of the vascular system that prevents blood loss during accidental disruption of the vessel wall. Late mechanisms of hemostasis comprise vessel repair and wound healing. In contrast, the early mechanism of hemostasis comprises the quick formation of a blood cell plug, also known as thrombus, whose function is to seal the region of the vessel near the compromised surface or area. Despite the simplicity of the concept, the molecular mechanisms underlying early hemostasis are highly complex. The local rheological properties of the blood flow, the vascular region and the nature of the injury determine the mechanism of thrombogenesis. Components of the plasma, blood cells such as platelets and vascular endothelial cells are involved in thrombosis. This review focuses on platelet-vascular wall interactions during thrombosis and hemostasis and provides an overview of the main underlying molecular mechanisms.
Export Options
About this article
Cite this article as:
Berna-Erro Alejandro, Redondo C. Pedro, Lopez Esther, Albarran Letizia and Rosado A. Juan, Molecular Interplay between Platelets and the Vascular Wall in Thrombosis and Hemostasis, Current Vascular Pharmacology 2013; 11 (4) . https://dx.doi.org/10.2174/1570161111311040006
DOI https://dx.doi.org/10.2174/1570161111311040006 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
Ischemic Cardiovascular Diseases: Mechanisms, Diagnosis and Therapy
Ischemic cardiovascular disease includes myocardial infarction, coronary atherosclerotic heart disease, angina pectoris, etc., constitute the leading cause of patient mortality by preventing tissues from getting sufficient oxygen and nutrients. Ischemic heart disease, as a clinical condition, is characterized by myocardial ischemia, causing an imbalance between myocardial blood supply and demand, ...read more
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Impaired Expression and Function of Cancer-Related Enzymes by Anthocyans: An Update
Current Enzyme Inhibition The Vitamin D/CYP24A1 Story in Cancer
Anti-Cancer Agents in Medicinal Chemistry EGF Receptor as a Drug Target in Arterial Hypertension
Mini-Reviews in Medicinal Chemistry Epigenetic Aberrations and Targeted Epigenetic Therapy of Esophageal Cancer
Current Cancer Drug Targets The Transcription Factor ETS-1: Its Role in Tumour Development and Strategies for its Inhibition
Mini-Reviews in Medicinal Chemistry Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin
Current Cancer Drug Targets Network Insights into the Genes Regulated by Hepatocyte Nuclear Factor 4 in Response to Drug Induced Perturbations: A Review
Current Drug Discovery Technologies Suppression of Cancer Invasiveness by Dietary Compounds
Mini-Reviews in Medicinal Chemistry Targeting Epithelial-Mesenchymal Transition Phenotype for Gastro-Intestinal Cancer
Current Pharmaceutical Design Lipoxygenase Inhibitors for Cancer Prevention: Promises and Risks
Current Pharmaceutical Design The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum
Current Neuropharmacology Chemoprotective and Carcinogenic Effects of tert-Butylhydroquinone and Its Metabolites
Current Drug Metabolism Chrysin Induces Apoptosis in Peripheral Blood Lymphocytes Isolated from Human Chronic Lymphocytic Leukemia
Anti-Cancer Agents in Medicinal Chemistry Gallic Acid Improved Amytryptiline Effect in Neuropathic Pain Induced by Partial Sciatic Nerve Ligation (PSNL) in Rats
The Natural Products Journal MDM2 Increases Drug Resistance in Cancer Cells by Inducing EMT Independent of p53
Current Medicinal Chemistry The Role of LncRNA TUG1 in Obesity-related Diseases
Mini-Reviews in Medicinal Chemistry Zoledronate Induced Hypocalcemia and Hypophosphatemia in Osteoporosis: A Cause of Concern
Current Drug Safety Targeting Cancer Stem Cells: Promises and Challenges
Anti-Cancer Agents in Medicinal Chemistry Pharmacogenetics of Colon Cancer and Potential Implications for 5- Fluorouracil-Based Chemotherapy
Current Pharmacogenomics Design of Combretastatin A-4 Analogs as Tubulin Targeted Vascular Disrupting Agent with Special Emphasis on Their Cis-Restricted Isomers
Current Pharmaceutical Design