Abstract
Nanoparticles of lyotropic liquid crystals loaded with a new photosensitizer (a chlorin derivative) were developed for use in photodynamic therapy (PDT). These systems were characterized by spectrofluorimetric, dynamic light scattering, and small angle X-ray diffraction (SAXRD) analyses. In vitro and in vivo penetration studies in animal models were performed using animal model membranes. The systems had a particle size of 161 ± 4 nm and a polydispersity index of 0.175 ± 0.027. Furthermore, SAXRD studies demonstrated that the preparations remained in the liquid crystalline phase type hexagonal after drug loading. The encapsulation rate was higher than 50%, and cell viability studies revealed that the nanodispersion is not harmful for L929 skin cells. In vitro and in vivo penetration studies confirmed that the nanodispersion of hexagonal phase enabled a higher drug skin uptake compared to the control. Additionally, a fluorescence microscopy study demonstrated a higher biodistribution of the chlorin derivative in the skin layers of hairless mice compared to the control. Taken together, the results show the potential of this nanodispersion for the delivery of the photosensitizer into the skin, which is a crucial condition for successful topical PDT.
Keywords: Photodynamic Therapy, skin delivery, chlorin, nanoparticles, liquid crystal.
Current Nanoscience
Title:Nanoparticles of Lyotropic Liquid Crystals: A Novel Strategy for the Topical Delivery of a Chlorin Derivative for Photodynamic Therapy of Skin Cancer
Volume: 9 Issue: 4
Author(s): Raquel Petrilli, Fabiola S.G. Praca, Aline Regina H. Carollo, Wanessa S.G. Medina, Kleber Thiago de Oliveira, Marcia C.A. Fantini, Maria da Graca P.M.S. Neves, Jose A.S. Cavaleiro, Osvaldo A. Serra, Yassuko Iamamoto and Maria Vitoria L.B. Bentley
Affiliation:
Keywords: Photodynamic Therapy, skin delivery, chlorin, nanoparticles, liquid crystal.
Abstract: Nanoparticles of lyotropic liquid crystals loaded with a new photosensitizer (a chlorin derivative) were developed for use in photodynamic therapy (PDT). These systems were characterized by spectrofluorimetric, dynamic light scattering, and small angle X-ray diffraction (SAXRD) analyses. In vitro and in vivo penetration studies in animal models were performed using animal model membranes. The systems had a particle size of 161 ± 4 nm and a polydispersity index of 0.175 ± 0.027. Furthermore, SAXRD studies demonstrated that the preparations remained in the liquid crystalline phase type hexagonal after drug loading. The encapsulation rate was higher than 50%, and cell viability studies revealed that the nanodispersion is not harmful for L929 skin cells. In vitro and in vivo penetration studies confirmed that the nanodispersion of hexagonal phase enabled a higher drug skin uptake compared to the control. Additionally, a fluorescence microscopy study demonstrated a higher biodistribution of the chlorin derivative in the skin layers of hairless mice compared to the control. Taken together, the results show the potential of this nanodispersion for the delivery of the photosensitizer into the skin, which is a crucial condition for successful topical PDT.
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Petrilli Raquel, Praca S.G. Fabiola, Carollo H. Aline Regina, Medina S.G. Wanessa, Oliveira de Kleber Thiago, Fantini C.A. Marcia, Neves P.M.S. Maria da Graca, Cavaleiro A.S. Jose, Serra A. Osvaldo, Iamamoto Yassuko and Bentley L.B. Maria Vitoria, Nanoparticles of Lyotropic Liquid Crystals: A Novel Strategy for the Topical Delivery of a Chlorin Derivative for Photodynamic Therapy of Skin Cancer, Current Nanoscience 2013; 9 (4) . https://dx.doi.org/10.2174/1573413711309040003
DOI https://dx.doi.org/10.2174/1573413711309040003 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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