Effects of Limonoid Cedrelone on MDA-MB-231 Breast Tumor Cells in vitro

Angelina   M.   Fuzer; Júlio   César C.   Filho; Amanda   B.   Becceneri; Damiana   A. dos   Santos; Maria   Fátima das G. F. da   Silva; Paulo   C.   Vieira; João   B.   Fernandes; Heloisa   S.   Selistre-de-Araujo; Cristiane   M.   Cazal; Márcia   R.   Cominetti

Abstract

Cancer is the second leading cause of death, preceded only by cardiovascular diseases, and there is epidemiological evidence that demonstrate this tendency is emerging worldwide. Brazil has an extensive vegetal biodiversity with more than 55,000 species listed. Such biodiversity collaborates with the finding of compounds which could be the basis for the design of new anti-tumor drugs, with fewer side effects than the conventional chemotherapy used currently. Cedrelone is a limonoid isolated from Trichilia catigua (Meliaceae) which is a native Brazilian plant. This study demonstrates that cedrelone inhibits proliferation, adhesion, migration and invasion of breast tumor cells from the line MDA-MB-231. The effects of cell migration and invasion on MDA-MB-231 cell may be explained, at least in part, by the ability of cedrelone to inhibit MMP activity. We also demonstrate that cedrelone is able to induce apoptosis in MDA-MB-231 cells. There are only a few works investigating the effect of limonoids in cellular processes closely related to tumor progression such as adhesion, migration and invasion. To the best of our knowledge, this is the first work describing the effects of a limonoid on tumor and non-tumor cell adhesion process.

Keywords: Apoptosis, cancer, cedrelone, cell adhesion, limonoid, natural products.

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