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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Copper and Iron-assisted Palladium-catalyzed Direct Arylation of Azoles with Arylboronic Acids under Ligand and Base-free Conditions

Author(s): Xiang-Mei Wu and Qiu-Xian Shen

Volume 10, Issue 9, 2013

Page: [668 - 673] Pages: 6

DOI: 10.2174/15701786113109990034

Abstract

The direct arylation of azoles with arylboronic acids is effectively promoted by PdCl2 in the presence of copper and iron salts under ligand and base-free conditions. This reaction can be applied to heterocycles such as benzothiazole, benzoxazole, 1-methylbenzimidazole and 4,5-dimethylthiazole with moderate to good yields.

Keywords: Palladium, copper, iron, arylation, arylboronic acid.


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