Abstract
The direct arylation of azoles with arylboronic acids is effectively promoted by PdCl2 in the presence of copper and iron salts under ligand and base-free conditions. This reaction can be applied to heterocycles such as benzothiazole, benzoxazole, 1-methylbenzimidazole and 4,5-dimethylthiazole with moderate to good yields.
Keywords: Palladium, copper, iron, arylation, arylboronic acid.
Letters in Organic Chemistry
Title:Copper and Iron-assisted Palladium-catalyzed Direct Arylation of Azoles with Arylboronic Acids under Ligand and Base-free Conditions
Volume: 10 Issue: 9
Author(s): Xiang-Mei Wu and Qiu-Xian Shen
Affiliation:
Keywords: Palladium, copper, iron, arylation, arylboronic acid.
Abstract: The direct arylation of azoles with arylboronic acids is effectively promoted by PdCl2 in the presence of copper and iron salts under ligand and base-free conditions. This reaction can be applied to heterocycles such as benzothiazole, benzoxazole, 1-methylbenzimidazole and 4,5-dimethylthiazole with moderate to good yields.
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Cite this article as:
Wu Xiang-Mei and Shen Qiu-Xian, Copper and Iron-assisted Palladium-catalyzed Direct Arylation of Azoles with Arylboronic Acids under Ligand and Base-free Conditions, Letters in Organic Chemistry 2013; 10 (9) . https://dx.doi.org/10.2174/15701786113109990034
DOI https://dx.doi.org/10.2174/15701786113109990034 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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