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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Glutamine, Glucose and other Fuels for Cancer

Author(s): Maria Victoria Ruiz-Perez, Francisca Sanchez-Jimenez, Francisco J. Alonso, Juan A. Segura, Javier Marquez and Miguel Angel Medina

Volume 20, Issue 15, 2014

Page: [2557 - 2579] Pages: 23

DOI: 10.2174/13816128113199990482

Price: $65

Abstract

Tumor cells suffer a metabolic reprogramming which allows them to use metabolic fuels (glucose, glutamine, lipids) through anabolic fates to support their enhanced proliferation and other carcinogenesis-related features. The present review tries to address and summarize the broad and growing information available about this reprogramming, whose pieces, put together, make up a complex scheme that encompasses different complexity scales, from cells to systemic networks.

Keywords: Aerobic glycolysis, cancer metabolism, glutaminolysis, metabolic reprogramming, tumor microenvironment.


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