Role of CNS Transporters in the Pharmacotherapy of HIV-1 Associated Neurological Disorders

Author(s): Tamima Ashraf, Kevin Robillard, Gary N.Y. Chan, Reina Bendayan.

Journal Name:Current Pharmaceutical Design

Volume 20 , Issue 10 , 2014

Abstract:

Membrane-associated drug transporters are important determinants of antiretroviral drug disposition in the central nervous system during HIV-1 infection. A number of influx and efflux transport proteins expressed at the blood-brain barrier, blood-cerebrospinal fluid barrier and in brain parenchyma cellular compartments (i.e., astrocytes, microglia) have been implicated in the traffic of many antiretroviral drugs into and out of the brain. In particular, members of the ATP-binding cassette membrane associated transporter superfamily and Solute Carrier family are known to be involved in the efflux and/or influx of drugs, respectively. As a result, changes in the functional expression of these transporters can alter the disposition and distribution of drugs in the brain. Moreover, antiretroviral therapy itself and/or pathological events (i.e., inflammation, oxidative stress) associated with viral infection may affect the functional expression of these transporters. This review summarizes recent knowledge on the role of drug transporters in regulating brain antiretroviral drug transport in the context of HIV-1 infection.

Keywords: HIV-1, brain, drug transport, ABC transporter, SLC transporter, antiretroviral drugs, neuropathogenesis.

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Article Details

VOLUME: 20
ISSUE: 10
Year: 2014
Page: [1543 - 1563]
Pages: 21
DOI: 10.2174/13816128113199990464
Price: $58

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