Predicting Drug-Target Interactions of Nuclear Receptors Based on Molecular Descriptors Information

Title:Predicting Drug-Target Interactions of Nuclear Receptors Based on Molecular Descriptors Information

Volume: 10 Issue: 10

Author(s): Junxiang Wang, Weiming Yu, Zhibin Chen, Hengda Li and Zhenran Jiang

Affiliation:

Keywords: Drug-target interaction, Molecular descriptors, Feature selection.

Abstract: Predicting the interaction between drugs and target proteins is one of the most important tasks for bioinformatics. Selecting suitable features for drug-target interaction prediction is an effective way for achieving this important goal. In this article, the molecular descriptors information of drugs combined with several important biological features of nuclear receptor (NR) proteins were first utilized for feature selection. Then, the incremental learning algorithm with support vector machines was used to obtain the optimal feature subset for drug-target interaction prediction. The results demonstrate that the feature selection method can lead to promising improvement on prediction accuracy of this target family.

Cite this article as:

Wang Junxiang, Yu Weiming, Chen Zhibin, Li Hengda and Jiang Zhenran, Predicting Drug-Target Interactions of Nuclear Receptors Based on Molecular Descriptors Information, Letters in Drug Design & Discovery 2013; 10 (10) . https://dx.doi.org/10.2174/15701808113109100023