Abstract
Diabetes mellitus is one of the major clinical problems worldwide. Previously, most of the investigational studies for identification of disease and new therapies were based on animal studies; however, present research methods involve high throughput screening, molecular targeting, nanotechnology for recent discovery of drugs and disease identification to combat against hazardous diseases like diabetes mellitus. In this review, we have depicted outlines enfolding various disease-specific animal modeling, sensing technologies, biomarker analysis, and novel scientific techniques that could be helpful in exploring the impending strategies for diabetes detection and treatment. To conclude, we believe that endorsement and upgrading of such novel high throughput screening assays and nanotechnology described herein may surely represent a significant improvement in the capability for screening and identifying the population at elevated risk of expected diabetes. Thereby in future, appreciation of such investigational techniques and technologies including metabolomics and genetic screening may help in early prediction of diabetes in patients at risk and may display a significant improvement over the researchers conducted after the declaration of the disease.
Keywords: Biomarkers, biosensors, Diabetic animal models, High throughput screening, oxidative stress, nonmaterials in diabetes, metabolic fingerprinting, glucolipotoxicity.
Current Diabetes Reviews
Title:An Overview of Valuable Scientific Models for Diabetes Mellitus
Volume: 9 Issue: 4
Author(s): Muhammad Sajid Hamid Akash, Kanwal Rehman and Shuqing Chen
Affiliation:
Keywords: Biomarkers, biosensors, Diabetic animal models, High throughput screening, oxidative stress, nonmaterials in diabetes, metabolic fingerprinting, glucolipotoxicity.
Abstract: Diabetes mellitus is one of the major clinical problems worldwide. Previously, most of the investigational studies for identification of disease and new therapies were based on animal studies; however, present research methods involve high throughput screening, molecular targeting, nanotechnology for recent discovery of drugs and disease identification to combat against hazardous diseases like diabetes mellitus. In this review, we have depicted outlines enfolding various disease-specific animal modeling, sensing technologies, biomarker analysis, and novel scientific techniques that could be helpful in exploring the impending strategies for diabetes detection and treatment. To conclude, we believe that endorsement and upgrading of such novel high throughput screening assays and nanotechnology described herein may surely represent a significant improvement in the capability for screening and identifying the population at elevated risk of expected diabetes. Thereby in future, appreciation of such investigational techniques and technologies including metabolomics and genetic screening may help in early prediction of diabetes in patients at risk and may display a significant improvement over the researchers conducted after the declaration of the disease.
Export Options
About this article
Cite this article as:
Akash Sajid Hamid Muhammad, Rehman Kanwal and Chen Shuqing, An Overview of Valuable Scientific Models for Diabetes Mellitus, Current Diabetes Reviews 2013; 9 (4) . https://dx.doi.org/10.2174/15733998113099990062
DOI https://dx.doi.org/10.2174/15733998113099990062 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Toward Greater Insights on Applications of Modeling and Simulation in Pregnancy
Current Drug Metabolism Abdominal Aortic Calcification: Clinical Significance, Mechanisms and Therapies
Current Pharmaceutical Design Research Trend of Persian Medicine Based on the PubMed Database, 2015 -2019
Current Traditional Medicine Hypothyroidism and Nephrotic Syndrome: Why, When and How to Treat
Current Vascular Pharmacology MRI of Pancreas in Patients with Chronic Pancreatitis and Healthy Volunteers: Can Pancreatic Signal Intensity and Contrast Enhancement Patterns be Valuable Predictors of Early Chronic Pancreatitis?
Current Medical Imaging Methotrexate Induced Pneumonitis: A Review Article
Current Respiratory Medicine Reviews GLP-1 as a Therapeutic Agent in Patients with Type 2 Diabetes Mellitus
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Physiologic Versus Diabetogenic Effects of Interleukin-1: A Question of Weight
Current Pharmaceutical Design Peptide and Non-peptide Antagonists Targeting Endothelin Receptors in Physiology and Pathology
Current Pharmaceutical Design The G Protein β3 Subunit Gene (GNB3) 825T Allele - a Thrifty Genotype
Current Genomics Current Perspectives on Anti-Aging Interventions
Letters in Drug Design & Discovery Quick-Release Bromocriptine for Treatment of Type 2 Diabetes
Current Drug Delivery “Metabolically Healthy” Obesity: Fact or Threat?
Current Diabetes Reviews Advanced Glycation End Products (AGEs) and their Involvement in Liver Disease
Current Pharmaceutical Design Therapeutic Angiogenesis for Peripheral Artery Diseases by Autologous Bone Marrow Cell Transplantation
Current Pharmaceutical Design Inpatient Diabetes Management in Non-ICU Settings: Evidence and Strategies
Current Diabetes Reviews Preface [Hot topic: Diabetes (Guest Editor: Alex M. DePaoli)]
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Hypertension in Pregnancy: A Review of Current Guidelines
Current Women`s Health Reviews Food Fortification with Omega-3 Fatty Acids; Microencapsulation as an Addition Method
Current Nutrition & Food Science HDL as a Target for Glycemic Control
Current Drug Targets